Hahn R G
Department of Anaesthesiology, Huddinge University Hospital, Sweden.
Urol Res. 1993;21(4):289-91. doi: 10.1007/BF00307714.
The serum concentration of glycine was measured at hourly intervals after administration of between 10 and 91 g glycine to 17 patients undergoing transurethral resection of the prostate and of between 15 and 22 g glycine to 18 volunteers by intravenous infusion. The apparent half-life of glycine varied 10-fold (range 26-245 min) and increased in direct proportion to the amount of glycine given. This result can be explained by assuming a marked intracellular accumulation of a surplus of glycine. The dose-dependent half-life means that patients who absorb large amounts of irrigating fluid are exposed to excessive blood levels of glycine for a prolonged period of time.
通过静脉输注，对17例接受经尿道前列腺切除术的患者给予10至91克甘氨酸，对18名志愿者给予15至22克甘氨酸，之后每隔一小时测量一次血清甘氨酸浓度。甘氨酸的表观半衰期变化了10倍（范围为26至245分钟），且与甘氨酸给药量成正比增加。该结果可通过假定甘氨酸过量在细胞内大量蓄积来解释。剂量依赖性半衰期意味着吸收大量冲洗液的患者会在较长时间内暴露于过高的血液甘氨酸水平。
