报告类风湿关节炎和中轴型脊柱关节炎患者 10 年以上的感知影响：系统文献回顾。
Reporting of patient-perceived impact of rheumatoid arthritis and axial spondyloarthritis over 10 years: a systematic literature review.
机构信息
UPMC Univ Paris 06, GRC-UPMC 08 (EEMOIS), Department of Rheumatology, AP-HP, Pitié Salpêtrière Hospital, UPMC Univ Paris 06, Department of Rheumatology, AP-HP, Saint Antoine Hospital, INSERM, UMRS 707, ESSEC Business School, Paris, THEMA, University of Cergy Pontoise, Cergy Pontoise, Fondation Arthritis, Neuilly, UCB Pharma, Colombes and Rheumatology Department, Cavale Blanche University Hospital and EA 2216, Université Bretagne Occidentale, Brest, France.UPMC Univ Paris 06, GRC-UPMC 08 (EEMOIS), Department of Rheumatology, AP-HP, Pitié Salpêtrière Hospital, UPMC Univ Paris 06, Department of Rheumatology, AP-HP, Saint Antoine Hospital, INSERM, UMRS 707, ESSEC Business School, Paris, THEMA, University of Cergy Pontoise, Cergy Pontoise, Fondation Arthritis, Neuilly, UCB Pharma, Colombes and Rheumatology Department, Cavale Blanche University Hospital and EA 2216, Université Bretagne Occidentale, Brest, France.
UPMC Univ Paris 06, GRC-UPMC 08 (EEMOIS), Department of Rheumatology, AP-HP, Pitié Salpêtrière Hospital, UPMC Univ Paris 06, Department of Rheumatology, AP-HP, Saint Antoine Hospital, INSERM, UMRS 707, ESSEC Business School, Paris, THEMA, University of Cergy Pontoise, Cergy Pontoise, Fondation Arthritis, Neuilly, UCB Pharma, Colombes and Rheumatology Department, Cavale Blanche University Hospital and EA 2216, Université Bretagne Occidentale, Brest, France.
出版信息
Rheumatology (Oxford). 2014 Jul;53(7):1274-81. doi: 10.1093/rheumatology/ket480. Epub 2014 Mar 6.
OBJECTIVE
RA and axial SpA have an important impact on patients' lives. The objective of this study was to explore the reporting of different aspects of that impact in publications, with a focus on differences between diseases and over time.
METHODS
A systematic literature review retrieved all articles reporting on the life impact of RA or axial radiographic SpA in adults published within the last 10 years and issued from European research. The data were classified into physical impact (including pain, functional assessment and fatigue), psychological impact (including psychological distress and coping) and social impact (including relationships, family and social life). The number of articles published over time was analysed by linear regression.
RESULTS
In all, 1352 abstracts were screened and 149 publications (40,056 patients) were analysed: 129 articles (86.5%) concerned RA and 16 (10.7%) concerned axial SpA. The mean number of articles reporting on the physical aspects of impact was 11.4 (s.d. 4.8) per 2-year period, but increased more than 2-fold (from 7 articles in 2001-3 to 15 in 2010-11), in particular due to recent publications on fatigue, whereas the number of articles on psychological aspects [mean 12.4 (s.d. 4.0)] decreased markedly after 2006. Publications reporting on social aspects [mean 8.2 (s.d. 4.1)] remained globally stable.
CONCLUSION
In the era of biologics, there is an interest in the patient-perceived life impact of RA and axial SpA in the European literature, but the impact of RA has been the subject of greater exploration. There are clearly trends over time in the reporting of impact.
目的
类风湿关节炎（RA）和中轴型脊柱关节炎（axial SpA）对患者的生活有重要影响。本研究的目的是探讨文献中对这些影响不同方面的报告，重点关注疾病之间和随时间的差异。
方法
系统文献回顾检索了过去 10 年内在欧洲开展的、报告 RA 或成人中轴型放射学 SpA 对生活影响的所有文章。数据分为身体影响（包括疼痛、功能评估和疲劳）、心理影响（包括心理困扰和应对）和社会影响（包括人际关系、家庭和社会生活）。通过线性回归分析随时间发表的文章数量。
结果
共筛选出 1352 篇摘要，分析了 149 篇出版物（40056 例患者）：129 篇（86.5%）涉及 RA，16 篇（10.7%）涉及中轴型 SpA。报告身体影响方面的文章数量平均为每 2 年 11.4 篇（标准差 4.8），但增加了两倍多（从 2001-2003 年的 7 篇增加到 2010-2011 年的 15 篇），这主要是由于最近发表了关于疲劳的文章，而关于心理方面的文章数量[平均 12.4 篇（标准差 4.0）]在 2006 年后明显减少。报告社会方面的文章数量[平均 8.2 篇（标准差 4.1）]总体保持稳定。
结论
在生物制剂时代，欧洲文献中对 RA 和中轴型 SpA 患者感知的生活影响有兴趣，但对 RA 的影响有更多的探索。报告影响的趋势随时间明显变化。
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