Mendes-da-Silva Cristiano, Giriko Catherine Ássuka, Mennitti Laís Vales, Hosoume Lilian Fazion, Souto Tayane dos Santos, Silva Alexandre Valotta da
Departamento de Biociências, Universidade Federal de São Paulo, SantosSP, Brazil, Departamento de Biociências, Universidade Federal de São Paulo, Santos SP, Brazil;
Universidade Federal de São Paulo, SantosSP, Brazil, Interdisciplinary Master in Health Sciences, Universidade Federal de São Paulo, Santos SP, Brazil;
Arq Neuropsiquiatr. 2014 Feb;72(2):136-44. doi: 10.1590/0004-282X20130220.
The maternal exposure to high fat diet (HFD) during pregnancy and breastfeeding have been considered an important inducer of alterations in offspring normal programming, both in animals and humans, and may disturb brain development. In the present study we investigated the somatic and sensory-motor development of the offspring from rat dams fed a HFD, compared with dams fed a control diet, during pregnancy or lactation. Indicators of the body growth, physical maturation, and reflex ontogeny were evaluated. Offspring of dams fed a HFD showed reduced weight and body growth, delayed physical maturation, and delayed maturation of the physiological reflexes, such as vibrissa placing, auditory startle response, and free-fall righting. Our findings suggest that maternal HFD during pregnancy or lactation modifies somatic and neurological development of the offspring, possibly increasing the risk of neuroendocrine and neuropsychiatric disorders later in life.
孕期和哺乳期母体高脂饮食（HFD）被认为是动物和人类后代正常程序改变的重要诱因，可能会干扰大脑发育。在本研究中，我们调查了孕期或哺乳期喂食高脂饮食的大鼠母鼠所产后代的躯体和感觉运动发育情况，并与喂食对照饮食的母鼠所产后代进行比较。评估了身体生长、身体成熟和反射个体发生的指标。喂食高脂饮食的母鼠所产后代体重和身体生长减少，身体成熟延迟，生理反射如触须放置、听觉惊吓反应和自由落体翻正反射的成熟也延迟。我们的研究结果表明，孕期或哺乳期母体高脂饮食会改变后代的躯体和神经发育，可能会增加其日后患神经内分泌和神经精神疾病的风险。
