Jackson Jamie L, Misiti Brian, Bridge Jeffrey A, Daniels Curt J, Vannatta Kathryn
Center for Biobehavioral Health, Nationwide Children's Hospital, Columbus, Ohio, USA; The Ohio State University College of Medicine, Columbus, Ohio, USA.
Congenit Heart Dis. 2015 Jan-Feb;10(1):2-12. doi: 10.1111/chd.12178. Epub 2014 Feb 26.
This study aimed to quantitatively compare findings of emotional functioning across studies of adolescents and adults with congenital heart disease (CHD) through meta-analysis.
The current meta-analysis included 22 studies of adolescent and adult survivors of CHD who completed measures of emotional functioning. Effect sizes were represented by Hedge's g. Heterogeneity was calculated and possible moderators (i.e., lesion severity, age, study location, study quality) were examined.
Overall, adolescent and adult survivors of CHD did not differ in emotional functioning from healthy controls or normative data. However, significant heterogeneity was found, and there was a trend for degree of lesion severity to moderate emotional functioning. Further analysis of lesion severity indicated that individuals with moderate lesions reported better emotional functioning than controls/normative data. Limitations in existing literature precluded examination of patient age as a moderator. Study location and quality did not explain a significant portion of the variance in effects.
Findings suggest that differences in emotional functioning may exist across lesion severities, and individuals with moderately severe lesions are emotionally thriving. Given the diversity within CHD lesion classifications, future studies should include other indicators of disease severity, such as measures of morbidity, to determine how disease may affect emotional functioning among survivors of CHD. Furthermore, authors and journals need to ensure that research is reported in enough detail to facilitate meta-analysis, a critically important tool in answering discrepancies in the literature.
本研究旨在通过荟萃分析定量比较先天性心脏病（CHD）青少年和成人研究中的情绪功能研究结果。
当前的荟萃分析纳入了22项关于CHD青少年和成人幸存者的研究，这些研究完成了情绪功能测量。效应大小用Hedge's g表示。计算了异质性，并检查了可能的调节因素（即病变严重程度、年龄、研究地点、研究质量）。
总体而言，CHD青少年和成人幸存者的情绪功能与健康对照组或常模数据没有差异。然而，发现了显著的异质性，并且病变严重程度有调节情绪功能的趋势。对病变严重程度的进一步分析表明，中度病变个体报告的情绪功能优于对照组/常模数据。现有文献的局限性排除了将患者年龄作为调节因素的检验。研究地点和质量并不能解释效应差异的很大一部分。
研究结果表明，不同病变严重程度的情绪功能可能存在差异，中度严重病变个体情绪状况良好。鉴于CHD病变分类的多样性，未来的研究应包括疾病严重程度的其他指标，如发病率测量，以确定疾病如何影响CHD幸存者的情绪功能。此外，作者和期刊需要确保研究报告足够详细，以促进荟萃分析，这是回答文献差异的一个至关重要的工具。
