Unit of Formation in Sciences Applied and Technological (UFR/SAT) and Institute of Sciences of the Environment and the Rural Development (ISEDR), Polytechnic University of Dédougou, Burkina Faso ; Laboratory of Biochemistry and Applied Chemistry, University of Ouagadougou, 09 P.O. Box 848, Ouagadougou 09, Burkina Faso.
Laboratory of Animal Physiology, UFR Bioscience, University of Felix Houphouet Boigny of Abidjan, 22 P.O. Box 582, Abidjan 22, Cote D'Ivoire.
Evid Based Complement Alternat Med. 2014;2014:867075. doi: 10.1155/2014/867075. Epub 2014 Jan 28.
Trichilia emetica and Opilia amentacea traditional Burkinabe medicinal plants were investigated to determine their therapeutic potential to inhibit key enzymes in carbohydrate metabolism, which has relevance to the management of type 2 diabetes. In vitro and in vivo antioxidant and antihypertensive potential and antilipidemia and antihyperglycemia activities in an animal model of type 2 diabetes mellitus have been studied. The antioxidant activity of the flavonoids from leaves of Trichilia emetica and Opilia amentacea has been evaluated using β -carotene-linoleic acid system, 1,1-diphenyl-2-picrylhydrazyl inhibitory activity, chelation of iron (II) ions, and lipid peroxidation which showed more pronounced antioxidant capacities of Trichilia emetica. Total cholesterol concentrations decreased in an animal model of type 2 diabetes mellitus under effects of flavonoid-rich fractions from leaves of Trichilia emetica and Opilia amentacea has been observed. Extract of flavonoid-rich fractions from Trichilia emetica shown maximum radical scavenging activity and possessed marked antiamylase activity which may be due to the presence of certain secondary metabolites. Suggested better antihyperglycemia, antilipidemia, and antihypertensive properties of flavonoid-rich fractions from Trichilia emetica compared to the extract of Opilia amentacea are demonstrating antidiabetic potential of Trichilia emetica as therapeutic targets for the management of type 2 diabetes.
研究了来自布基纳法索的传统药用植物 Trichilia emetica 和 Opilia amentacea，以确定它们抑制碳水化合物代谢关键酶的治疗潜力，这与 2 型糖尿病的管理有关。研究了它们在体外和体内的抗氧化和降压潜力以及在 2 型糖尿病动物模型中的抗脂血症和降血糖活性。使用β-胡萝卜素-亚油酸体系、1,1-二苯基-2-苦基肼抑制活性、铁（II）离子螯合和脂质过氧化评估了来自 Trichilia emetica 和 Opilia amentacea 叶的类黄酮的抗氧化活性，结果表明 Trichilia emetica 具有更明显的抗氧化能力。在 2 型糖尿病动物模型中观察到富含类黄酮的叶提取物对总胆固醇浓度的影响。从 Trichilia emetica 中分离出的富含类黄酮的部分提取物具有最大的自由基清除活性，并具有明显的抗淀粉酶活性，这可能是由于存在某些次生代谢物。与 Opilia amentacea 的提取物相比，富含类黄酮的部分提取物显示出更好的降血糖、抗脂血症和降压特性，表明 Trichilia emetica 具有抗糖尿病潜力，可作为 2 型糖尿病管理的治疗靶点。
