Experimental Cardiology, Cardiovascular Research Institute Maastricht (CARIM), Maastricht University, Universiteitssingel 50, 6229 ER, Maastricht, The Netherlands.
Pflugers Arch. 2014 Jun;466(6):1177-87. doi: 10.1007/s00424-014-1479-1. Epub 2014 Mar 13.
Heart failure as a consequence of ischemic, hypertensive, infectious, or hereditary heart disease is a major challenge in cardiology and topic of intense research. Recently, new players appeared in this field and promise deeper insights into cardiac development, function, and disease. Long non-coding RNAs are a novel class of transcripts that can regulate gene expression and may have many more functions inside the cell. Here, we present examples on long non-coding RNA (lncRNA) function in cardiac development and give suggestions on how lncRNAs may be involved in cardiomyocyte dysfunction, myocardial fibrosis, and inflammation, three hallmarks of the failing heart. Above that, we point out opportunities as well as challenges that should be considered in the endeavor to investigate cardiac lncRNAs.
心力衰竭是缺血性、高血压性、感染性或遗传性心脏病的主要并发症，是心脏病学的一个主要挑战，也是一个研究热点。最近，该领域出现了一些新的参与者，它们有望更深入地了解心脏的发育、功能和疾病。长非编码 RNA 是一类新型的转录本，可以调节基因表达，在细胞内可能具有更多的功能。在这里，我们介绍了长非编码 RNA（lncRNA）在心脏发育中的功能的实例，并就 lncRNA 如何参与心肌细胞功能障碍、心肌纤维化和炎症（心力衰竭的三个特征）提出了建议。此外，我们还指出了在研究心脏 lncRNA 时应考虑的机会和挑战。
