Armed Forces Research Institute of Medical Sciences (USAMC-AFRIMS), Phnom Penh, Cambodia.
Malar J. 2014 Mar 14;13:96. doi: 10.1186/1475-2875-13-96.
The mechanism of massive intravascular haemolysis occurring during the treatment of malaria infection resulting in haemoglobinuria, commonly known as blackwater fever (BWF), remains unknown. BWF is most often seen in those with severe malaria treated with amino-alcohol drugs, including quinine, mefloquine and halofantrine. The potential for drugs containing artemisinins, chloroquine or piperaquine to cause oxidant haemolysis is believed to be much lower, particularly during treatment of uncomplicated malaria. Here is an unusual case of BWF, which developed on day 2 of treatment for uncomplicated Plasmodium falciparum infection with dihydroartemisinin-piperaquine (DHA-PIP) with documented evidence of concomitant seropositivity for Chikungunya infection.
在治疗疟疾感染导致血红蛋白尿（俗称黑尿热，BWF）期间，大量血管内溶血的发生机制尚不清楚。BWF 最常发生于接受氨基醇类药物（包括奎宁、甲氟喹和卤泛群）治疗的重症疟疾患者。含青蒿素类、氯喹或哌喹的药物引起氧化溶血的可能性被认为要低得多，尤其是在治疗单纯性疟疾期间。这里报告了 1 例不常见的 BWF 病例，患者在接受二氢青蒿素-哌喹（DHA-PIP）治疗单纯性恶性疟原虫感染的第 2 天发生了 BWF，同时有基孔肯雅热感染的血清学阳性证据。
