Van den Ende J, Coppens G, Verstraeten T, Van Haegenborgh T, Depraetere K, Van Gompel A, Van den Enden E, Clerinx J, Colebunders R, Peetermans W E, Schroyens W
Institute of Tropical Medicine, Antwerp, Belgium.
Trop Med Int Health. 1998 Aug;3(8):632-9. doi: 10.1046/j.1365-3156.1998.00287.x.
Five cases of blackwater fever (BWF) are described, all of whom had a history of recent quinine therapy. In two cases a second haemolytic crisis was induced by halofantrine, in one case also a third. Increasing frequency of this syndrome with its dramatic clinical presentation is to be expected as imported P. falciparum infection, parasite resistance to chloroquine and the use of quinine and other related antimalarials become more frequent.
本文描述了5例黑水热（BWF）病例，所有患者近期均有奎宁治疗史。其中2例因卤泛群诱发了第二次溶血危机，1例还诱发了第三次。随着输入性恶性疟原虫感染、寄生虫对氯喹耐药以及奎宁和其他相关抗疟药的使用日益频繁，预计这种具有显著临床表现的综合征的发病率将会增加。
