Cocate Paula G, Natali Antônio José, Oliveira Alessandro de, Longo Giana Z, Alfenas Rita de Cássia G, Peluzio Maria do Carmo G, Santos Eliziária C dos, Buthers Jéssica M, Oliveira Leandro L de, Hermsdorff Helen Hermana M
Department of Nutrition and Health, Federal University of Viçosa, Viçosa, Minas Gerais, Brazil.
Departament of Physical Education, Federal University of Viçosa, Viçosa, Minas Gerais, Brazil.
Nutrition. 2014 Jun;30(6):660-5. doi: 10.1016/j.nut.2013.10.015. Epub 2013 Oct 30.
The aim of this cross-sectional study was to assess the potential relationships between fruit and vegetable (FV) intake and oxidative stress markers in middle-aged men, with an emphasis on vitamin C, fiber, and magnesium content.
The study was conducted with 296 healthy men, age 50.5 ± 5.0 y, and body mass index (BMI) of 25.8 ± 3.5 kg/m(2). Dietary intake, anthropometry, blood pressure, lifestyle features, and blood and urine biochemical data were assessed with validated procedures. The oxidative stress markers selected were plasma oxidized low-density lipoprotein (ox-LDL), urinary 8-iso-prostaglandin F2 α (8-iso-PGF2 α) and 8-hydroxy-2'-deoxyguanosine (8-OHdG).
The men included in the highest tertile of FV intake (≥341.1 g/d) displayed lower concentrations of ox-LDL, 8-iso-PGF2 α and 8-OHdG (P for trend < 0.05), regardless of confounding factors. Concentrations of ox-LDL were negatively associated with fiber from the FV intake (P for trend < 0.05) regardless of confounding factors. ox-LDL and 8-OHdG concentrations tended to be lower in the higher tertile of magnesium (P for trend = 0.06) and vitamin C from FV intake (P for trend = 0.05), respectively. Additionally, concentrations of 8-iso-PGF2 α were lower in men in the highest tertile of fiber (≥6.5 g/d; P for trend = 0.034), vitamin C (≥98.0 mg/d; P for trend = 0.007), and magnesium (≥48.9 mg/d; P for trend = 0.018) from the FV-group intake.
Greater FV intake was independently associated with reduced ox-LDL, 8-OHdG, and 8-iso-PGF2 α in middle-aged men. Fiber, vitamin C, and magnesium from FV seem to contribute to this beneficial relationship.
本横断面研究旨在评估中年男性水果和蔬菜（FV）摄入量与氧化应激标志物之间的潜在关系，重点关注维生素C、纤维和镁的含量。
该研究对296名健康男性进行，年龄为50.5±5.0岁，体重指数（BMI）为25.8±3.5kg/m²。采用经过验证的程序评估饮食摄入量、人体测量学指标、血压、生活方式特征以及血液和尿液生化数据。所选的氧化应激标志物为血浆氧化型低密度脂蛋白（ox-LDL）、尿8-异前列腺素F2α（8-iso-PGF2α）和8-羟基-2'-脱氧鸟苷（8-OHdG）。
无论混杂因素如何，FV摄入量处于最高三分位数（≥341.1g/d）的男性，其ox-LDL、8-iso-PGF2α和8-OHdG的浓度较低（趋势P<0.05）。无论混杂因素如何，ox-LDL浓度与FV摄入量中的纤维呈负相关（趋势P<0.05）。镁（趋势P=0.06）和FV摄入量中的维生素C（趋势P=0.05）处于较高三分位数时，ox-LDL和8-OHdG浓度往往较低。此外，FV组摄入量中纤维（≥6.5g/d；趋势P=0.034）、维生素C（≥98.0mg/d；趋势P=0.007）和镁（≥48.9mg/d；趋势P=0.018）处于最高三分位数的男性，其8-iso-PGF2α浓度较低。
中年男性中，较高的FV摄入量与ox-LDL、8-OHdG和8-iso-PGF2α的降低独立相关。FV中的纤维维生素C和镁似乎促成了这种有益关系。
