Mozes G, Friedman N, Shainkin-Kestenbaum R
Department of Orthopaedic Surgery, Soroka Medical Center, Ben-Gurion University of the Negev, Faculty of Health Sciences, Beer Sheva, Israel.
J Trauma. 1989 Jan;29(1):71-4.
Acute response after traumatic events was studied in serial serum samples of 21 patients over a period of 13 days. Among the various biochemical and hematologic parameters, serum amyloid A (SAA) exhibited the most striking changes, with a pattern similar to that of the tissue marker creatine-P kinase (CPK). Maximal SAA level was detected 3-4 days after onset of the event, and reached 216 +/- 41 SEM gm/ml (normal range less than 2 gm/ml), while maximal CPK level was detected on the same day and reached 530 +/- 242 SEM IU/L (normal range 24-195 IU/L). Fibrinogen, leucocytes, platelets, albumin, alkaline phosphatase (AP), and calcium (Ca) each showed its own typical pattern of change. Fever did not develop. Comparison of SAA levels after various acute events suggests that damage to the myocardium is the most powerful stimulus for SAA induction, followed by traumatic events, arthritis, viral infections, and malignant diseases. It seems therefore that although acute response is considered a generalized reaction, it is not completely independent of the localized events which induce it. Among the known parameters, SAA is the most sensitive marker for monitoring the intensity of events.
对21例患者的系列血清样本进行了为期13天的创伤事件后急性反应研究。在各种生化和血液学参数中，血清淀粉样蛋白A（SAA）表现出最显著的变化，其模式与组织标志物肌酸磷酸激酶（CPK）相似。事件发生后3 - 4天检测到SAA的最高水平，达到216±41 SEM μg/ml（正常范围小于2 μg/ml），而CPK的最高水平在同一天检测到，达到530±242 SEM IU/L（正常范围24 - 195 IU/L）。纤维蛋白原、白细胞、血小板、白蛋白、碱性磷酸酶（AP）和钙（Ca）各自呈现出其典型的变化模式。未出现发热。对各种急性事件后SAA水平的比较表明，心肌损伤是诱导SAA的最有力刺激因素，其次是创伤事件、关节炎、病毒感染和恶性疾病。因此，似乎尽管急性反应被认为是一种全身性反应，但它并非完全独立于诱导它的局部事件。在已知参数中，SAA是监测事件强度的最敏感标志物。
