Liverpool School of Tropical Medicine, Pembroke Place, Liverpool, L3 5QA, UK.
Liverpool School of Tropical Medicine, Pembroke Place, Liverpool, L3 5QA, UK; Warwick Systems Biology Centre, Senate House, University of Warwick, Coventry, CV4 7AL, UK.
Trends Parasitol. 2014 Apr;30(4):170-5. doi: 10.1016/j.pt.2014.02.001. Epub 2014 Mar 11.
We hypothesise that intraerythrocytic malaria parasite metabolism is not merely fulfilling the need for ATP generation, but is evolved to support rapid proliferation, similar to that seen in other rapidly proliferating cells such as cancer cells. Deregulated glycolytic activity coupled with impaired mitochondrial metabolism is a metabolic strategy to generate glycolytic intermediates essential for rapid biomass generation for schizogony. Further, we discuss the possibility that Plasmodium metabolism is not only a functional consequence of the 'hard-wired' genome and argue that metabolism may also have a causal role in triggering the cascade of events that leads to developmental stage transitions. This hypothesis offers a framework to rationalise the observations of aerobic glycolysis, atypical mitochondrial metabolism, and metabolic switching in nonproliferating stages.
我们假设，疟原虫在红细胞内的代谢不仅满足了 ATP 生成的需要，而且还进化到支持快速增殖，类似于癌细胞等其他快速增殖的细胞。糖酵解活性失调加上线粒体代谢受损是一种代谢策略，可产生裂殖体快速产生生物量所必需的糖酵解中间产物。此外，我们还讨论了疟原虫代谢不仅是“硬连线”基因组的功能后果的可能性，并认为代谢也可能在触发导致发育阶段转变的一系列事件中起因果作用。这一假说为合理化有氧糖酵解、非典型线粒体代谢和非增殖阶段代谢转换的观察结果提供了一个框架。
