Institute of Pharmacology, Biochemical-Pharmacological Center (BPC) Marburg; University of Marburg; Marburg, Germany.
Nucleus. 2014 Jan-Feb;5(1):15-20. doi: 10.4161/nucl.28066. Epub 2014 Feb 3.
Many if not most proteins can, under certain conditions, change cellular compartments, such as, for example, shuttling from the cytoplasm to the nucleus. Thus, many proteins may exert functions in various and very different subcellular locations, depending on the signaling context. A large amount of actin regulatory proteins has been detected in the mammalian cell nucleus, although their potential roles are much debated and are just beginning to emerge. Recently, members of the formin family of actin nucleators were also reported to dynamically localize to the nuclear environment. Here we discuss our findings that specific diaphanous-related formins can promote nuclear actin assembly in a signal-dependent manner.
许多（如果不是大多数）蛋白质在某些条件下可以改变细胞区室，例如，从细胞质到细胞核的穿梭。因此，许多蛋白质可能根据信号环境在各种非常不同的亚细胞位置发挥作用。尽管其潜在作用仍存在争议，并且才刚刚开始显现，但哺乳动物细胞核中已经检测到大量的肌动蛋白调节蛋白。最近，肌动蛋白成核因子formin 家族的成员也被报道可以动态定位到核环境。在这里，我们讨论了我们的发现，即特定的果蝇同源物formin 可以以信号依赖的方式促进核肌动蛋白组装。
