Egbe Christopher Aye, Enabulele Onaiwu Idahosa
Department of Medical Microbiology University of Benin Teaching Hospital, PMB 1111, Benin City, Nigeria.
Department of Microbiology, Faculty of Life Sciences, University of Benin, PMB 1154, Benin City, Nigeria.
Malays J Med Sci. 2014 Jan;21(1):37-43.
Malaria parasitaemia is an important predictor of bacteremia, concomitant invasive bacterial infections and malaria parasitaemia are strongly associated with death.
Blood samples were collected from 500 patients (281 males and 219 females) with fevers of unknown origin. The blood samples were processed to diagnose malaria and bacterial septicaemia using standard microbiological techniques.
The prevalence of concomitant bacterial septicaemia and malaria parasitaemia was 7.8%. The prevalence of malaria parasitaemia alone (26.2%) was significantly (P < 0.0001) higher than that of bacterial septicaemia (13%). Patients 61 years old and older had higher prevalences of malaria parasitaemia, bacterial septicaemia, and concomitant infections. The most prevalent organism causing bacterial septicaemia were of the Klebsiella species, while ceftriaxone and ceftazidime were the most effective antibacterial agents.
Overall prevalence of malaria parasitaemia, septicaemia and concomitant malaria parasitaemia, and bacterial septicaemia were 26.2%, 13%, and 7.8%, respectively. Bacteria from the Klebsiella species were the most common bacteria causing septicaemia. Although ceftriaxone and ceftazidime are the recommended treatments, there is need for urgent treatment of concomitant infections due to their poor prognosis.
疟原虫血症是菌血症的重要预测指标，同时侵袭性细菌感染与疟原虫血症密切相关，且二者均与死亡密切相关。
收集500例不明原因发热患者（281例男性和219例女性）的血样。采用标准微生物技术对血样进行处理，以诊断疟疾和细菌性败血症。
合并细菌性败血症和疟原虫血症的患病率为7.8%。单纯疟原虫血症的患病率（26.2%）显著高于细菌性败血症（13%）（P < 0.0001）。61岁及以上患者的疟原虫血症、细菌性败血症及合并感染的患病率更高。引起细菌性败血症最常见的病原体是克雷伯菌属，而头孢曲松和头孢他啶是最有效的抗菌药物。
疟原虫血症、败血症、合并疟原虫血症和细菌性败血症的总体患病率分别为26.2%、13%和7.8%。克雷伯菌属细菌是引起败血症最常见的细菌。尽管头孢曲松和头孢他啶是推荐的治疗药物，但由于合并感染预后较差，仍需要紧急治疗。
