Manarelli M M, Delbem A C B, Binhardi T D R, Pessan J P
Department of Pediatric Dentistry and Public Health, Araçatuba Dental School, Univ. Estadual Paulista (UNESP), Rua Jose Bonifacio 1193, 16015-050, Araçatuba, SP, Brazil.
Clin Oral Investig. 2015 Nov;19(8):2141-6. doi: 10.1007/s00784-015-1492-6. Epub 2015 May 14.
This study analyzed the effects of a fluoride (F) varnish supplemented with sodium trimetaphosphate (TMP) on the remineralization of caries-like lesions in situ.
Twelve subjects used palatal devices with demineralized enamel discs for 3 days, following a double-blind, crossover protocol. Test groups included placebo (no F or TMP), 5% NaF and 5% NaF/5% TMP varnishes. The percentage of surface hardness recovery (%SHR) and cross-sectional hardness (ΔKHN) were determined.
Significant differences were observed among all varnishes regarding %SHR and ΔKHN. The highest %SHR and the lowest ΔKHN were seen for the 5% NaF/5% TMP varnish, followed by 5% NaF and placebo.
The remineralizing effect of a 5% NaF varnish is significantly enhanced when associated with TMP.
The reduction in the subsurface lesion area of enamel treated with the TMP-containing varnish implies that cavities would take longer to develop or might not develop at all depending on individual factors, resulting in lower net caries increments at individual and population levels.
本研究分析了添加三聚偏磷酸钠（TMP）的氟化物（F）清漆对原位龋样病变再矿化的影响。
12名受试者按照双盲、交叉方案，使用带有脱矿釉质圆盘的腭部装置3天。测试组包括安慰剂（不含F或TMP）、5% NaF和5% NaF/5% TMP清漆。测定表面硬度恢复百分比（%SHR）和横截面硬度（ΔKHN）。
在所有清漆的%SHR和ΔKHN方面观察到显著差异。5% NaF/5% TMP清漆的%SHR最高，ΔKHN最低，其次是5% NaF和安慰剂。
5% NaF清漆与TMP联合使用时，其再矿化效果显著增强。
用含TMP的清漆处理的釉质表面下病变面积减小，这意味着龋洞形成所需时间会更长，或者根据个体因素可能根本不会形成，从而在个体和群体水平上导致较低的净龋增量。
