Zhou Ru, Qian Shiguang, Gu Xiaodong, Chen Zongyou, Xiang Jianbin
Department of General Surgery, Huashan Hospital, Fudan University, Shanghai 200040, P.R. China.
Department of Immunology and General Surgery, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, OH 44195, USA.
Biomed Rep. 2013 Sep;1(5):687-690. doi: 10.3892/br.2013.132. Epub 2013 Jul 11.
Interleukin (IL)-13 is an immunoregulatory cytokine secreted by numerous immune cells. Its functions are similar to those of IL-4 and they share a common receptor. This cytokine has been included in recent studies on human tumors and malignant diseases, evoking a scientific interest to investigate the role of IL-13 and its receptors as novel biomarkers and targets for therapy. Colorectal cancer is one of the most common human malignancies, its prognosis is not promising and the efficacy of molecular-targeted therapy has not been established. This review summarizes the currently available data on the role of IL-13 and its receptors in colorectal cancer, including the signaling pathways involved in mediating the effects of IL-13, the role of IL-13 and/or its receptors in the prediction of cancer and several drugs targeting IL-13 or its receptors that are currently under evaluation.
白细胞介素（IL）-13是一种由多种免疫细胞分泌的免疫调节细胞因子。其功能与IL-4相似，且它们共享一个共同的受体。这种细胞因子已被纳入近期关于人类肿瘤和恶性疾病的研究中，引发了对研究IL-13及其受体作为新型生物标志物和治疗靶点作用的科学兴趣。结直肠癌是最常见的人类恶性肿瘤之一，其预后不佳，分子靶向治疗的疗效尚未确立。本综述总结了目前关于IL-13及其受体在结直肠癌中作用的可用数据，包括介导IL-13作用的信号通路、IL-13和/或其受体在癌症预测中的作用以及几种目前正在评估的靶向IL-13或其受体的药物。
