Charig C R, Rundle J S
Institute of Urology, London, England.
Urology. 1989 Mar;33(3):175-8. doi: 10.1016/0090-4295(89)90385-3.
Orchiectomy is considered a safe and simple procedure, free from serious side effects, in the treatment of prostatic carcinoma. We have found that 76 percent of patients experienced postorchiectomy flushes, and 30 percent believed their symptoms warranted treatment. The flushing started at between one and twelve months (average 2.7 months) postoperatively and lasted an average of thirty months or, in some cases, up to the time of death (average 33 months). No single precipitating factor was found, and no single hormone seemed to be responsible. Special attention was given to the nonflushers to see whether or not it was of prognostic significance, and it appears that the slight elevation in the testosterone level sufficient to prevent flushing may indicate a nontesticular source of androgen. Medroxyprogesterone acetate (Provera), 5 mg twice daily, appeared to be an effective agent for controlling the flushes.
睾丸切除术在前列腺癌治疗中被认为是一种安全、简单的手术，且无严重副作用。我们发现，76%的患者在睾丸切除术后出现潮热，30%的患者认为其症状需要治疗。潮热在术后1至12个月（平均2.7个月）开始，平均持续30个月，在某些情况下，直至死亡（平均33个月）。未发现单一的诱发因素，似乎也没有单一激素对此负责。我们对未出现潮热的患者给予了特别关注，以观察这是否具有预后意义，似乎足以防止潮热的睾酮水平轻微升高可能表明雄激素的非睾丸来源。醋酸甲羟孕酮（安宫黄体酮），每日两次，每次5毫克，似乎是控制潮热的有效药物。
