宫颈细胞学检查与多种 HPV 感染：8182 例 31-65 岁女性研究。
Cervical cytology and multiple type HPV infection: a study of 8182 women ages 31-65.
机构信息
Department of Obstetrics, Gynecology and Women's Health, and Masonic Cancer Center, University of Minnesota, Minneapolis, MN, USA.
Biostatistics and Bioinformatics Core, Masonic Cancer Center, University of Minnesota, Minneapolis, MN, USA.
出版信息
Gynecol Oncol. 2014 Jun;133(3):405-8. doi: 10.1016/j.ygyno.2014.03.552. Epub 2014 Mar 20.
OBJECTIVE
The aim of this study is to determine the rates of single and multiple type human papillomavirus (HPV) infection in women in the United States ages 31-65 with known cervical cytology results.
METHODS
Type-specific HPV analyses were conducted using the first samples of women who had HPV typing performed by Access Genetics as part of cervical cancer screening between July 2007 and May 2011. Women 31-65years at testing with associated abnormal cytology results were included. The odds of abnormal cytology (compared to normal results) for multiple vs. single HPV infections were calculated for each cytology sub-type and odds ratios (OR) and 95% confidence intervals (CI) are reported.
RESULTS
The analysis included 8182 women. The majority (67.7%) had ASCUS cervical cytology. A total of 329 (4.0%) were positive for 2 or more HPV types. For all cervical cytology subtypes considered (ASCUS, ASCUS-H, LSIL or HSIL), women with multiple type infections were more likely to have abnormal cytology (compared to normal cytology) with the highest OR associated with HSIL (OR 1.81 (1.26-2.60)). When analyzing HPV type 16 alone, women with multiple type infections were more likely to have abnormal cytology, with the highest OR associated with HSIL cytology (OR 2.98 (1.57-5.64)). Few women had HPV type 18 infections and no results reached statistical significance. Results based on phylogenic family organization focusing on the alpha 9 phylogenic family showed similar results as HPV type 16.
CONCLUSIONS
Women ages 31-65 with multiple type HPV infections were more likely to have abnormal cytology than those with single HPV type infections.
目的
本研究旨在确定美国年龄在 31-65 岁之间、已知宫颈细胞学结果的女性中，单一和多重人乳头瘤病毒（HPV）感染的发生率。
方法
采用 Access Genetics 公司进行 HPV 分型的女性的首份样本进行 HPV 型别分析，这些女性是在 2007 年 7 月至 2011 年 5 月期间作为宫颈癌筛查的一部分进行 HPV 分型的。纳入了检测时年龄在 31-65 岁之间且伴有异常细胞学结果的女性。计算多重 HPV 感染与单一 HPV 感染相比，在各细胞学亚型中异常细胞学（与正常结果相比）的比值比（OR）和 95%置信区间（CI）。
结果
该分析共纳入 8182 名女性。大多数（67.7%）的宫颈细胞学为 ASCUS。共有 329 名（4.0%）女性为 2 种或更多 HPV 型别阳性。对于考虑的所有宫颈细胞学亚型（ASCUS、ASCUS-H、LSIL 或 HSIL），多重 HPV 感染的女性更有可能出现异常细胞学（与正常细胞学相比），与 HSIL 相关的 OR 最高（OR 1.81（1.26-2.60））。当单独分析 HPV 型 16 时，多重 HPV 感染的女性更有可能出现异常细胞学，与 HSIL 细胞学相关的 OR 最高（OR 2.98（1.57-5.64））。很少有女性感染 HPV 型 18，且结果均未达到统计学意义。基于针对 alpha 9 进化枝家族的进化枝组织分析，结果与 HPV 型 16 相似。
结论
与单一 HPV 型感染相比，31-65 岁的多重 HPV 感染女性更有可能出现异常细胞学。
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