Eur J Nucl Med Mol Imaging. 2014 May;41 Suppl 1:S91-103. doi: 10.1007/s00259-013-2566-9.
Hybrid cardiac single photon emission computed tomography (SPECT)/CT imaging allows combined assessment of anatomical and functional aspects of cardiac disease. In coronary artery disease (CAD), hybrid SPECT/CT imaging allows detection of coronary artery stenosis and myocardial perfusion abnormalities. The clinical value of hybrid imaging has been documented in several subsets of patients. In selected groups of patients, hybrid imaging improves the diagnostic accuracy to detect CAD compared to the single imaging techniques. Additionally, this approach facilitates functional interrogation of coronary stenoses and guidance with regard to revascularization procedures. Moreover, the anatomical information obtained from CT coronary angiography or coronary artery calcium scores (CACS) adds prognostic information over perfusion data from SPECT. The use of cardiac hybrid imaging has been favoured by the dissemination of dedicated hybrid systems and the release of dedicated image fusion software, which allow simple patient throughput for hybrid SPECT/CT studies. Further technological improvements such as more efficient detector technology to allow for low-radiation protocols, ultra-fast image acquisition and improved low-noise image reconstruction algorithms will be instrumental to further promote hybrid SPECT/CT in research and clinical practice.
心脏混合单光子发射计算机断层扫描（SPECT）/CT 成像可结合评估心脏疾病的解剖和功能方面。在冠状动脉疾病（CAD）中，混合 SPECT/CT 成像可检测冠状动脉狭窄和心肌灌注异常。混合成像的临床价值已在多个亚组患者中得到证实。在选择的患者群体中，与单一成像技术相比，混合成像可提高诊断 CAD 的准确性。此外，这种方法有助于对冠状动脉狭窄进行功能评估，并指导血运重建术。此外，CT 冠状动脉造影或冠状动脉钙化评分（CACS）获得的解剖学信息可提供比 SPECT 灌注数据更具预后意义的信息。专用混合系统的普及和专用图像融合软件的发布促进了心脏混合成像的应用，这些系统允许混合 SPECT/CT 研究的患者简单通过。进一步的技术改进，例如更高效的探测器技术以实现低辐射方案、超快图像采集和改进的低噪声图像重建算法，将有助于进一步推动混合 SPECT/CT 在研究和临床实践中的应用。
