J Cancer Res Clin Oncol. 2014 Sep;140(9):1451-6. doi: 10.1007/s00432-014-1649-8.
Gastric cancer is one of the most common malignant diseases worldwide, although much progress has been achieved in recent years, the early diagnosis and treatment for gastric cancer are not yet satisfactory and, thus the prognosis is still poor. MicroRNAs (miRNAs) can regulate a variety of physiological and developmental processes, it has been revealed that many miRNAs contribute the initiation and progression of various cancers. MiR-148a is one of the most important miRNAs in gastric cancer, and the aim of this paper is to provide an overview of various roles of miR-148a in gastric cancer.
We searched studies in electronic databases. MiR-148a was down-regulated in gastric cancer tissues and cell lines, which was resulted from the hypermethylation in its promoter region. Furthermore, miR-148a could regulate several different target genes and pathways involving tumor proliferation, invasion and metastasis.
MiR-148a may serve as a novel biomarker for the diagnosis and as a new therapeutic target in gastric cancer.
胃癌是全球最常见的恶性疾病之一，尽管近年来取得了许多进展，但胃癌的早期诊断和治疗仍不尽如人意，因此预后仍然较差。微小 RNA（miRNA）可以调节多种生理和发育过程，已经发现许多 miRNA 有助于各种癌症的发生和发展。miR-148a 是胃癌中最重要的 miRNA 之一，本文旨在综述 miR-148a 在胃癌中的各种作用。
我们在电子数据库中搜索了研究。miR-148a 在胃癌组织和细胞系中下调，这是由于其启动子区域的过度甲基化所致。此外，miR-148a 可以调节涉及肿瘤增殖、侵袭和转移的几个不同的靶基因和途径。
miR-148a 可能作为胃癌诊断的新型生物标志物，并作为新的治疗靶点。
