Lim Jung-eun, Jee Sun Ha
Institute for Health Promotion & Department of Epidemiology and Health Promotion, Graduate School of Public Health, Yonsei University, Seoul, Republic of Korea.
Endocrine. 2015 Feb;48(1):211-7. doi: 10.1007/s12020-014-0231-0. Epub 2014 Mar 25.
Persistent organic pollutants (POPs) are endocrine-disrupting chemicals associated with metabolic syndrome and type 2 diabetes. In humans, little is known about their potential role on obesity. Adiponectin augments the effects of insulin on glucose homeostasis. The expression of adiponectin is reduced in obesity, insulin resistance, and type 2 diabetes. The aim of this study is to reveal whether accumulation of the POPs, especially polychlorinated biphenyls (PCBs), is associated with serum levels of adiponectin in Koreans. This cross-sectional study includes 98 Koreans (49 men and 49 women). Serum levels of marker PCBs (PCB 28, 52, 101, 138, 153, and 180) were measured by Agilent 7890GC-micro-ECD (Gas chromatography-micro-electron capture detector). Total adiponectin levels were quantified by enzyme-linked immunosorbent assay. We defined high (≥Median) and low (<Median) body mass index (BMI) groups by using median value of BMI (24.6 kg/m2 for men; 23.0 kg/m2 for women). PCB28, PCB138, and PCB153 were significantly negatively associated with adiponectin levels (β-coefficients=-0.00741 for PCB28; -0.00438 for PCB138; -0.00406 for PCB153). When we divided subjects by sex, PCB28 and PCB153 were inversely associated with adiponectin in women. In the high BMI group (≥Median), PCB153 showed the significant negative associations with adiponectin levels (P<0.05). However, these associations were not seen in the low BMI group. In conclusion, we found negative associations between PCBs and adiponectin. This cross-sectional study could provide support for the hypothesis that POPs exposure might contribute to type 2 diabetes as well as obesity.
持久性有机污染物（POPs）是与代谢综合征和2型糖尿病相关的内分泌干扰化学物质。在人类中，关于它们在肥胖方面的潜在作用知之甚少。脂联素可增强胰岛素对葡萄糖稳态的作用。肥胖、胰岛素抵抗和2型糖尿病患者的脂联素表达会降低。本研究的目的是揭示持久性有机污染物，尤其是多氯联苯（PCBs）的蓄积是否与韩国人的血清脂联素水平相关。这项横断面研究纳入了98名韩国人（49名男性和49名女性）。通过安捷伦7890GC-微电子捕获检测器（气相色谱-微电子捕获检测器）测定血清中多氯联苯标志物（PCB 28、52、101、138、153和180）的水平。通过酶联免疫吸附测定法定量总脂联素水平。我们使用体重指数（BMI）的中位数（男性为24.6 kg/m²；女性为23.0 kg/m²）将受试者分为高（≥中位数）和低（<中位数）BMI组。PCB28、PCB138和PCB153与脂联素水平呈显著负相关（PCB28的β系数=-0.00741；PCB138的β系数=-0.00438；PCB153的β系数=-0.00406）。当我们按性别对受试者进行划分时，PCB28和PCB153与女性脂联素呈负相关。在高BMI组（≥中位数）中，PCB153与脂联素水平呈显著负相关（P<0.05）。然而，在低BMI组中未观察到这些相关性。总之，我们发现多氯联苯与脂联素之间存在负相关。这项横断面研究可为持久性有机污染物暴露可能导致2型糖尿病和肥胖这一假说提供支持。
