State Key Laboratory of Synthetic Chemistry, Institute of Molecular Functional Materials and Department of Chemistry, The University of Hong Kong, Pokfulam Road, Hong Kong.
Adv Mater. 2014 Aug 20;26(31):5550-7. doi: 10.1002/adma.201305617. Epub 2014 Mar 24.
The therapeutic applications of many anticancer or antimicrobial metal complexes often suffer from low solubility and low stability in physiological conditions or from drug resistance. To circumvent these problems, nanoparticle systems that allow controlled release and specific accumulation in the targeted disease tissue are of advantage for efficient treatment with minimal toxicity. The focus of this Research News is metal-based nanomaterials comprising anticancer gold(III)/platinum(II) complexes or antimicrobial silver, highlighting the controlled-release properties of self-assembled metal systems.
许多抗癌或抗微生物金属配合物的治疗应用往往受到低溶解度和低稳定性的限制，在生理条件下或耐药性。为了克服这些问题，允许在靶向疾病组织中控制释放和特异性积累的纳米粒子系统有利于高效治疗，毒性最小。本研究新闻的重点是包含抗癌金（III）/铂（II）配合物或抗微生物银的基于金属的纳米材料，强调自组装金属系统的控制释放特性。
