Materials and Science Engineering, Division of Materials Technology, Nanyang Technological University , Singapore 639798, Republic of Singapore.
ACS Appl Mater Interfaces. 2014 Apr 23;6(8):5749-58. doi: 10.1021/am500454b. Epub 2014 Apr 9.
Plasma treatments are investigated as a post-production method of tuning drug release and bioadhesion of poly(lactic-co-glycolic acid) (PLGA) thin films. PLGA films were treated under varying conditions by controlling gas flow rate, composition, treatment time, and radio frequency (RF) power. In vitro release of the drug-like molecule fluorescein diacetate (FDAc) from plasma-treated PLGA was tunable by controlling RF power; an increase of 65% cumulative release is reported compared to controls. Bioadhesion was sensitive to RF power and treatment time, assessed using ex vivo shear-stress tests with wetted swine aorta. We report a maximum bioadhesion ∼6-fold that of controls and 5-fold that of DOPA-based mussel adhesives tested to swine skin.1 The novelty of this post-treatment is the activation of a hydrophobic polyester film for bioadhesion, which can be quenched, while simultaneously tuning drug-release kinetics. This exemplifies the promise of plasma post-treatment for in-clinic bioadhesive activation, along with technological advancements, i.e., atmospheric plasma and hand-held "plasma pencils".
等离子体处理被研究作为一种后生产方法，用于调节聚（乳酸-共-乙醇酸）（PLGA）薄膜的药物释放和生物粘附性。通过控制气体流量、组成、处理时间和射频（RF）功率，PLGA 薄膜在不同条件下进行处理。通过控制 RF 功率，可调节类似药物分子荧光素二乙酸酯（FDAc）从等离子体处理的 PLGA 中的释放；与对照相比，报告了累积释放增加了 65%。生物粘附性对 RF 功率和处理时间敏感，使用湿润的猪主动脉进行体外剪切应力测试进行评估。我们报告了最大生物粘附性约为对照的 6 倍，是测试到猪皮的 DOPA 基贻贝类胶粘剂的 5 倍。1 这种后处理的新颖之处在于激活了用于生物粘附的疏水性聚酯膜，同时可以调整药物释放动力学。这说明了等离子体后处理在临床生物粘附激活方面的前景，以及技术进步，例如大气压等离子体和手持式“等离子体笔”。
