Zhadkevich M M, Baratova L A, Matveev D V
Lab Delo. 1989(2):29-32.
Blood plasma amino acid levels in 10 patients with peritonitis are analyzed. Nonsurvivors, in contrast to survivors, had severe amino acid derangements. Aminoacidemia and amino acid imbalance were registered early in the course of the illness. Increased concentrations of aromatic amino acids: phenylalanine and tyrosine, and low concentrations of branched-chain amino acids: valine, leucine, and isoleucine were associated with a decrease of Fisher's index (BCAA/AAA molar ratio) from 3.0 +/- 0.5 (normal) to 2.0 +/- 0.5 which was of high diagnostic and prognostic significance. The nature of such imbalance and its role in protein derangements are discussed.
分析了10例腹膜炎患者的血浆氨基酸水平。与幸存者相比,非幸存者存在严重的氨基酸紊乱。在疾病过程早期就出现了氨基酸血症和氨基酸失衡。芳香族氨基酸(苯丙氨酸和酪氨酸)浓度升高,而支链氨基酸(缬氨酸、亮氨酸和异亮氨酸)浓度降低,这与费舍尔指数(支链氨基酸/芳香族氨基酸摩尔比)从3.0±0.5(正常)降至2.0±0.5相关,这具有很高的诊断和预后意义。讨论了这种失衡的性质及其在蛋白质紊乱中的作用。