Zhang Zili, Wang Jian, Chen Sifan, Wei Zhaoyu, Li Zhengtu, Zhao Siwen, Lu Wenju
State Key Laboratory of Respiratory Diseases, Guangzhou Institute of Respiratory Disease, The First Affiliated Hospital, Guangzhou Medical University, Guangzhou, Guangdong, China.
Department of Nutrition, School of Public Health, Sun Yat-Sen University, Guangzhou, Guangdong, China.
PLoS One. 2014 Mar 26;9(3):e92609. doi: 10.1371/journal.pone.0092609. eCollection 2014.
Low plasma level of high density lipoprotein cholesterol (HDL-c) was an independent risk factor for cardio vascular disorder, and associated with poor outcomes in pulmonary arterial hypertension. To compare the effects of vegetarian diets and omnivorous diets on HDL-c in plasma, we identified cross-sectional and cohort studies related to HDL-c listed on PubMed and ISI Web of Knowledge as well as the corresponding references (until Nov, 2013). Twelve studies with a total of 4177 individuals were selected for meta-analysis. This meta-analysis indicates that vegetarian diets did not alter plasma HDL-c concentrations, as it wasn't initially expected by the authors [Standardized Mean Difference (SMD) = 0.02 mmol/l; 95% confidence interval (CI): -0.19 to 0.22 mmol/l]. In Asia and Latin America countries, no significant differences in HDL-c levels between vegetarians and omnivores were found (SMD = -0.09 mmol/l; 95% CI: -0.43 to 0.25 mmol/l). In Europe and North America countries, the plasma level of HDL-c was also not different between the two diets (SMD = 0.09 mmol/l; 95% CI: -0.19 to 0.36 mmol/l). In light of this meta-analysis, we conclude that there is no evidence that plasma HDL-c levels differs in vegetarians and omnivores, even after adjusting for cultural circumstances.
血浆高密度脂蛋白胆固醇（HDL-c）水平低是心血管疾病的独立危险因素，且与肺动脉高压的不良预后相关。为比较素食饮食和杂食饮食对血浆HDL-c的影响，我们在PubMed和ISI Web of Knowledge以及相应参考文献（截至2013年11月）中检索了与HDL-c相关的横断面研究和队列研究。选取12项研究共4177名个体进行荟萃分析。该荟萃分析表明，素食饮食并未改变血浆HDL-c浓度，这并非作者最初所预期的[标准化均数差（SMD）=0.02 mmol/l；95%置信区间（CI）：-0.19至0.22 mmol/l]。在亚洲和拉丁美洲国家，素食者和杂食者的HDL-c水平未发现显著差异（SMD=-0.09 mmol/l；95% CI：-0.43至0.25 mmol/l）。在欧洲和北美国家，两种饮食的血浆HDL-c水平也无差异（SMD=0.09 mmol/l；95% CI：-0.19至0.36 mmol/l）。基于该荟萃分析，我们得出结论，即使校正文化背景因素，也没有证据表明素食者和杂食者的血浆HDL-c水平存在差异。
