衰老研究的密集测量设计
Intensive Measurement Designs for Research on Aging.
作者信息
Rast Philippe, Macdonald Stuart W S, Hofer Scott M
机构信息
Department of Psychology, University of Victoria.
出版信息
GeroPsych (Bern). 2012;25(2):45-55. doi: 10.1024/1662-9647/a000054.
Abstract
Intensive measurement burst designs permit analysis of behavioral and biological processes as they unfold over short and long periods of time and providing the opportunity to identify change from an individual's normative level of functioning. The measurement burst design permits statistical decomposition of short-term variation and learning effects that overlay normative aging and provide stronger bases for detecting accelerated change due to pathological processes. We provide an overview of design features and analysis of measurement burst data in Project MIND. The objective of intensive measurement designs is to obtain greater resolution of processes of interest that permit reliable and sensitive assessments of functioning and change in functioning and of key determinants underlying short-term variation and long-term aging and health-related change.
摘要
密集测量突发设计允许分析行为和生物过程，因为它们在短时间和长时间内展开，并提供了从个体正常功能水平识别变化的机会。测量突发设计允许对短期变化和学习效应进行统计分解，这些效应叠加在正常衰老之上，并为检测由于病理过程导致的加速变化提供了更强的基础。我们概述了项目MIND中的设计特征和测量突发数据的分析。密集测量设计的目标是获得对感兴趣过程的更高分辨率，从而能够对功能和功能变化以及短期变化和长期衰老及健康相关变化的关键决定因素进行可靠和敏感的评估。
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