Mohammadi Rasoul, Nazeri Mehdi, Sayedayn Sayed Mohammad Amin, Ehteram Hassan
Department of Medical Parasitology and Mycology, Faculty of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.
Department of Parasitology, School of Medicine, Kashan University of Medical Sciences, Kashan, Iran.
J Res Med Sci. 2014 Jan;19(1):72-4.
Mucormycosis is an invasive fungal infection caused by filamentous fungi of the Mucoraceae family. The genera most commonly responsible are Mucor or Rhizopus. The disease occurs mostly in association with diabetic ketoacidosis. Mucormycosis has an extremely high death rate even when aggressive surgery is done. Death rates range from 25-85% depending on the body area involved. A case of rhinocerebral mucormycosis in a 65-year-old diabetic male patient typically presenting as headache, especially in parietal and frontal lobes, with nose and left eye discharge. After clinical and laboratory examination, mucormycosis was diagnosed, and Rhizopus oryzae was isolated. Systemic therapy with amphotericin B administered intravenously then replaced by posaconazole by a combination of aggressive surgery. The patient was treated and followed up for one year. We emphasize the importance of early detection and aggressive treatment in the management of this fatal disease.
毛霉病是一种由毛霉科丝状真菌引起的侵袭性真菌感染。最常见的致病属是毛霉属或根霉属。该疾病大多与糖尿病酮症酸中毒相关。即使进行积极的手术治疗，毛霉病的死亡率仍极高。根据受累身体部位的不同，死亡率在25%至85%之间。一名65岁的糖尿病男性患者发生鼻脑型毛霉病，典型表现为头痛，尤其是顶叶和额叶，伴有鼻和左眼分泌物。经过临床和实验室检查，确诊为毛霉病，并分离出米根霉。静脉注射两性霉素B进行全身治疗，随后在积极手术的同时改用泊沙康唑。对该患者进行了为期一年的治疗和随访。我们强调在这种致命疾病的管理中早期检测和积极治疗的重要性。
