韩国炎症性肠病患者疲劳严重程度及与高疲劳水平相关的因素。
Fatigue severity and factors associated with high fatigue levels in Korean patients with inflammatory bowel disease.
机构信息
Department of Internal Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Korea.
出版信息
Gut Liver. 2014 Mar;8(2):148-53. doi: 10.5009/gnl.2014.8.2.148. Epub 2013 Nov 5.
BACKGROUND/AIMS: Many patients with inflammatory bowel disease (IBD) often complain of fatigue. To date, only a few studies in Western countries have focused on fatigue related to IBD, and fatigue has never been specifically studied in Asian IBD patients. The aim of the present study was to investigate the fatigue level and fatigue-related factors among Korean IBD patients.
METHODS
Patients in remission or with mild to moderate IBD were included. Fatigue was assessed using the Functional Assessment of Chronic Illness Therapy-Fatigue and the Brief Fatigue Inventory. Corresponding healthy controls (HCs) also completed both fatigue questionnaires.
RESULTS
Sixty patients with Crohn disease and 68 patients with ulcerative colitis (UC) were eligible for analysis. The comparison group consisted of 92 HCs. Compared with the HCs, both IBD groups were associated with greater levels of fatigue (p<0.001). Factors influencing the fatigue score in UC patients included anemia and a high erythrocyte sedimentation rate (ESR).
CONCLUSIONS
Greater levels of fatigue were detected in Korean IBD patients compared with HCs. Anemia and ESR were determinants of fatigue in UC patients. Physicians need to be aware of fatigue as one of the important symptoms of IBD to better understand the impact of fatigue on health-related quality of life.
背景/目的：许多炎症性肠病（IBD）患者常抱怨疲劳。迄今为止，只有少数西方国家的研究关注与 IBD 相关的疲劳，而亚洲的 IBD 患者从未对此进行过专门研究。本研究旨在调查韩国 IBD 患者的疲劳水平和与疲劳相关的因素。
方法
纳入缓解期或轻中度 IBD 患者。采用慢性疾病治疗功能评估-疲劳量表和简明疲劳量表评估疲劳。相应的健康对照组（HCs）也完成了这两种疲劳问卷。
结果
60 例克罗恩病患者和 68 例溃疡性结肠炎（UC）患者符合纳入标准。比较组由 92 名 HCs 组成。与 HCs 相比，IBD 两组的疲劳水平均更高（p<0.001）。影响 UC 患者疲劳评分的因素包括贫血和高红细胞沉降率（ESR）。
结论
与 HCs 相比，韩国 IBD 患者的疲劳水平更高。贫血和 ESR 是 UC 患者疲劳的决定因素。医生需要意识到疲劳是 IBD 的重要症状之一，以更好地了解疲劳对健康相关生活质量的影响。
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