University of São Paulo, School of Physical Education and Sport, Av. Prof. Mello Moraes, 65-05508-030, São Paulo, SP, Brazil,
J Cachexia Sarcopenia Muscle. 2014 Jun;5(2):105-10. doi: 10.1007/s13539-014-0138-x. Epub 2014 Mar 28.
Cancer cachexia is a complex multifactorial syndrome characterized by loss of skeletal muscle mass (with or without loss of fat mass) that cannot be fully reversed by conventional nutritional support and leads to progressive functional impairment. Recently, some amino acids and other amine dietary supplements have been highlighted in medical field due to positive effects upon diseases evolving skeletal muscle atrophy. Therefore, the aim of this brief review is to discuss the putative application of amines as dietary supplements to counteract skeletal muscle wasting on cancer cachexia. Specifically, we focus in two nutritional supplements: (1) branched-chain amino acids (BCAAs) and (2) creatine. Both BCAAs and creatine may attenuate proteolysis and enhance proteins synthesis in skeletal muscle. Although more experimental studies and clinical trials are still necessary to elucidate this therapeutic application, several evidences have demonstrated that amines supplementation is a promising coadjuvant treatment to cancer cachexia.
癌症恶病质是一种复杂的多因素综合征，其特征是骨骼肌质量（伴有或不伴有脂肪质量损失）的损失，不能通过常规营养支持完全逆转，并导致进行性功能障碍。最近，一些氨基酸和其他胺类膳食补充剂在医学领域因其对骨骼肌肉萎缩相关疾病的积极影响而受到关注。因此，本综述的目的是讨论胺类作为膳食补充剂在对抗癌症恶病质引起的骨骼肌消耗中的潜在应用。具体来说，我们关注两种营养补充剂：（1）支链氨基酸（BCAAs）和（2）肌酸。BCAAs 和肌酸都可以减少骨骼肌的蛋白水解并增加蛋白质的合成。尽管还需要更多的实验研究和临床试验来阐明这种治疗应用，但有几项证据表明，胺类补充剂是癌症恶病质的一种有前途的辅助治疗方法。
