Jeon HoJun, Simon Carl G, Kim GeunHyung
Department of Bio-Mechatronic Engineering, College of Biotechnology and Bioengineering, Sungkyunkwan University, Suwon, South Korea.
J Biomed Mater Res B Appl Biomater. 2014 Oct;102(7):1580-94. doi: 10.1002/jbm.b.33158. Epub 2014 Mar 28.
Cellular behavior can be influenced by the chemical and physical surface characteristics of biomedical substrates. To understand the relationships between various topographical surface patterns and cellular activities, various types of pattern models have been developed and examined in a range of sizes (microscale, nanoscale, and hierarchical structures consisting of both) and shapes (pillar, hole, groove, grate, grid, and island). Here, we review fabrication methods for obtaining physically patterned microscale and nanoscale surfaces, and discuss the relationships between cellular responses and physically patterned surfaces, which could be applied to various biomedical scaffolds used in tissue engineering applications.
细胞行为会受到生物医学基质的化学和物理表面特性的影响。为了理解各种拓扑表面图案与细胞活动之间的关系，已经开发并研究了各种类型的图案模型，其尺寸范围涵盖微尺度、纳尺度以及由二者组成的分级结构，形状包括柱状、孔状、槽状、篦状、网格状和岛状。在此，我们综述了用于获得物理图案化微尺度和纳尺度表面的制造方法，并讨论细胞反应与物理图案化表面之间的关系，这些关系可应用于组织工程应用中使用的各种生物医学支架。
