Koeser Joachim, Carvalho Thiago Saads, Pieles Uwe, Lussi Adrian
Institute for Chemistry and Bioanalytics, University of Applied Sciences and Arts Northwestern Switzerland, Gruendenstrasse 40, 4132, Muttenz, Switzerland,
J Mater Sci Mater Med. 2014 Jul;25(7):1671-7. doi: 10.1007/s10856-014-5200-x. Epub 2014 Mar 30.
Fluorides are used in dental care due to their beneficial effect in tooth enamel de-/remineralization cycles. To achieve a desired constant supply of soluble fluorides in the oral cavity, different approaches have been followed. Here we present results on the preparation of CaF2 particles and their characterization with respect to a potential application as enamel associated fluoride releasing reservoirs. CaF2 particles were synthesized by precipitation from soluble NaF and CaCl2 salt solutions of defined concentrations and their morphology analyzed by scanning electron microscopy. CaF2 particles with defined sizes and shapes could be synthesized by adjusting the concentrations of the precursor salt solutions. Such particles interacted with enamel surfaces when applied at fluoride concentrations correlating to typical dental care products. Fluoride release from the synthesized CaF2 particles was observed to be largely influenced by the concentration of phosphate in the solution. Physiological solutions with phosphate concentration similar to saliva (3.5 mM) reduced the fluoride release from pure CaF2 particles by a factor of 10-20 × as compared to phosphate free buffer solutions. Fluoride release was even lower in human saliva. The fluoride release could be increased by the addition of phosphate in substoichiometric amounts during CaF2 particle synthesis. The presented results demonstrate that the morphology and fluoride release characteristics of CaF2 particles can be tuned and provide evidence of the suitability of synthetic CaF2 particles as enamel associated fluoride reservoirs.
由于氟化物在牙釉质脱矿/再矿化循环中具有有益作用，因此被用于牙科护理。为了在口腔中实现所需的可溶性氟化物持续供应，人们采用了不同的方法。在此，我们展示了关于CaF2颗粒制备的结果及其作为牙釉质相关氟化物释放储库潜在应用的表征。通过从特定浓度的可溶性NaF和CaCl2盐溶液中沉淀合成CaF2颗粒，并通过扫描电子显微镜分析其形态。通过调节前体盐溶液的浓度，可以合成具有特定尺寸和形状的CaF2颗粒。当以与典型牙科护理产品相关的氟化物浓度应用时，此类颗粒会与牙釉质表面相互作用。观察到合成的CaF2颗粒的氟化物释放很大程度上受溶液中磷酸盐浓度的影响。与无磷酸盐缓冲溶液相比，磷酸盐浓度与唾液相似（3.5 mM）的生理溶液使纯CaF2颗粒的氟化物释放降低了10 - 20倍。在人类唾液中氟化物释放甚至更低。在CaF2颗粒合成过程中添加亚化学计量的磷酸盐可以增加氟化物释放。所呈现的结果表明，可以调节CaF2颗粒的形态和氟化物释放特性，并提供了合成CaF2颗粒作为牙釉质相关氟化物储库适用性的证据。
