从基因组到社会：人类健康决定因素的整体观。
From genomes to societies: a holistic view of determinants of human health.
机构信息
Department of Family and Preventive Medicine, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA.
Department of Bioengineering, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA.
出版信息
Curr Opin Biotechnol. 2014 Aug;28:134-42. doi: 10.1016/j.copbio.2014.03.001. Epub 2014 Mar 28.
Both biological and social sciences have identified contributing factors to human health. However, health outcomes are unlikely to equal a simple sum of these identified factors. This article makes an attempt to put together the information, methods, and technologies that relate to health outcomes from biological, behavioral, and social disciplines. Much of this information was obtained by controlling for the variations of the factors in 'other' disciplines. For example, genetic factors were controlled for in identifying the behavioral determinants of health. Looking forward, better understandings of health outcomes may require exploiting the interactions of health determinants that were identified from different disciplines. We propose the concept of 'systems health' studies, which take health outcomes as the outputs of a system, where the inputs and their interactions from multiple disciplines are considered.
生物科学和社会科学都已经确定了影响人类健康的因素。然而，健康结果不太可能等同于这些已确定因素的简单总和。本文试图将与生物、行为和社会学科相关的健康结果的信息、方法和技术结合在一起。这些信息中的大部分是通过控制“其他”学科中因素的变化获得的。例如，在确定健康行为决定因素时，控制遗传因素。展望未来，要更好地了解健康结果，可能需要利用从不同学科确定的健康决定因素之间的相互作用。我们提出了“系统健康”研究的概念，将健康结果视为系统的输出，其中考虑了来自多个学科的输入及其相互作用。
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