Kathleen Mullan Harris is with the Department of Sociology, Carolina Population Center, and Carolina Center for Genome Sciences, University of North Carolina at Chapel Hill. Carolyn Tucker Halpern and Jon Hussey are with the Department of Maternal and Child Health, Gillings School of Global Public Health and Carolina Population Center, University of North Carolina at Chapel Hill. Eric A. Whitsel is with the Departments of Epidemiology, Gillings School of Global Public Health, and Medicine, School of Medicine, University of North Carolina at Chapel Hill. Ley Killeya-Jones and Joyce Tabor are with the Carolina Population Center, University of North Carolina at Chapel Hill. Glen Elder is with the Department of Sociology and Carolina Population Center, University of North Carolina at Chapel Hill. John Hewitt is with the Department of Psychology and the Institute for Behavioral Genetics, University of Colorado at Boulder. Michael Shanahan is with the Department of Sociology and Carolina Center for Genome Sciences, University of North Carolina at Chapel Hill. Redford Williams and Ilene Siegler are with Duke University Medical Center, Durham, NC. Andrew Smolen is with the Institute for Behavioral Genetics, University of Colorado at Boulder.
Am J Public Health. 2013 Oct;103 Suppl 1(Suppl 1):S25-32. doi: 10.2105/AJPH.2012.301181. Epub 2013 Aug 8.
The influence of genetic factors on health and behavior is conditioned by social, cultural, institutional, and physical environments in which individuals live, work, and play. We encourage studies supporting multilevel integrative approaches to understanding these contributions to health, and describe the Add Health study as an exemplar. Add Health is a large sample of US adolescents in grades 7 to 12 in 1994-1995 followed into adulthood with 4 in-home interviews and biomarker collections, including DNA. In addition to sampling multiple environments and measuring diverse social and health behavior, Add Health features a fully articulated behavioral genetic sample (3000 pairs) and ongoing genotyping of 12,000 archived samples. We illustrate approaches to understanding health through investigation of the interplay among biological, psychosocial, and physical, contextual, or cultural experiences.
遗传因素对健康和行为的影响受到个体生活、工作和娱乐的社会、文化、制度和物理环境的制约。我们鼓励支持多层次综合方法来理解这些对健康的贡献，并将 Add Health 研究描述为一个范例。Add Health 是一项对 1994-1995 年美国 7 至 12 年级青少年的大型样本研究，这些青少年在成年后接受了 4 次家访和生物标志物采集，包括 DNA。除了对多种环境进行抽样和测量多样化的社会和健康行为外，Add Health 还具有一个完整的行为遗传样本（3000 对），并对 12000 个存档样本进行持续基因分型。我们通过研究生物、心理社会和物理、环境或文化经验之间的相互作用来展示通过调查理解健康的方法。
