兔肺VX2肿瘤模型中影像引导下经皮微波消融的实验研究
Experimental study of image-guided percutaneous microwave ablation in rabbit lung VX2 tumor model.
作者信息
Li Xin, Liu Weixing, Kou Haiyan, Zhou Weihua, Li Tao, Dong Baowei, Liang Ping
机构信息
Department of Ultrasound, Chinese General Hospital of Armed Police Forces No. 69 Yongding Road, Beijing 100039, China ; Department of Interventional Ultrasound, Chinese PLA General Hospital No. 28 Fuxing Road, Beijing 100853, China.
Department of Ultrasound, Chinese General Hospital of Armed Police Forces No. 69 Yongding Road, Beijing 100039, China.
出版信息
Int J Clin Exp Pathol. 2014 Feb 15;7(3):905-13. eCollection 2014.
PURPOSE
To investigate the efficacy and safety of percutaneous microwave ablation.
METHODS
Twenty-six rabbits with lung VX2 tumor were randomly divided into experimental and control group. In the experimental group, microwave ablation guided by ultrasound or CT was performed based on location of the tumor. Enhanced CT scan was carried out immediately before and after the ablation for all animals. Two animals from each group were sacrificed immediately or 1 week after the ablation respectively and the others were followed for the rest of their lives.
RESULTS
CT scan revealed that the tumor was greatly reduced or ablated after ablation. Pathological examination immediately after ablation also confirmed the tumor reduction or ablation. The survival time of the animals in the experimental group was significantly longer than that in the control group.
CONCLUSIONS
Microwave ablation is a safe and effective method for treating lung cancer in rabbits, showing potential clinical applicability.
目的
探讨经皮微波消融的疗效及安全性。
方法
将26只患有VX2肺癌的兔子随机分为实验组和对照组。实验组根据肿瘤位置在超声或CT引导下进行微波消融。所有动物在消融前后均立即进行增强CT扫描。每组分别有2只动物在消融后立即或1周后处死，其余动物进行终身随访。
结果
CT扫描显示消融后肿瘤明显缩小或被消融。消融后立即进行的病理检查也证实了肿瘤缩小或被消融。实验组动物的生存时间明显长于对照组。
结论
微波消融是治疗兔肺癌的一种安全有效的方法，具有潜在的临床应用价值。
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