Ajdari Zahra, Abd Ghani Maaruf, Khan Ayob Mohd, Bayat Saadi, Mokhtar Mazlin, Abbasiliasi Sahar, Khoramnia Anahita, Rahman Heshu Sulaiman, Mehrbod Parvaneh, Ajdari Daniel, Ariff Arbakariya B
School of Chemical Sciences & Food Technology, Faculty of Science & Technology, MANIS Lab, Universiti Kebangsaan Malaysia, 43600 Bangi, Selangor, Malaysia ; Department of Marine Biotechnology, Iranian Fisheries Research Organization, No. 297, West Fatemi Avenue, P.O. Box 14155-6116, Tehran 1411816616, Iran.
School of Chemical Sciences & Food Technology, Faculty of Science & Technology, MANIS Lab, Universiti Kebangsaan Malaysia, 43600 Bangi, Selangor, Malaysia.
ScientificWorldJournal. 2014 Feb 20;2014:252647. doi: 10.1155/2014/252647. eCollection 2014.
Hypercholesterolemia is one of the most common chronic diseases in human. Along with chemical therapy traditional medication is used as hypocholesterolemic remedy, however, with unfavorable side effects. Recently, Monascus fermented product (MFP) has become a popular hypocholesterolemic natural supplement. In the present study, the hypocholesterolemic activity of Monascus purpureus FTC5391 fermented product ethanolic extract (MFPe) was investigated in hypercholesterolemic rats. Results showed that MFPe not only reduced the serum total cholesterol (TC), LDL-C, TG concentration, and TC/HDL-C ratio but also increased the HDL-C. Further, solid phase extraction (SPE) was carried out to obtain the hypocholesterolemic bioactive fraction. The high polar fraction of SPE increased the HDL-C (42%) and decreased the TC (53.3%), LDL-C (47%), and TG (50.7%) levels as well as TC/HDL-C ratio (69.1%) in serum. The GC-MS results of the active fraction revealed two main compounds, isosorbide and erythritol, which act as coronary vasodilator compounds.
高胆固醇血症是人类最常见的慢性病之一。除了化学疗法外，传统药物也被用作降胆固醇药物，然而，这些药物存在不良副作用。最近，红曲发酵产品（MFP）已成为一种流行的降胆固醇天然补充剂。在本研究中，研究了紫红红曲FTC5391发酵产品乙醇提取物（MFPe）对高胆固醇血症大鼠的降胆固醇活性。结果表明，MFPe不仅降低了血清总胆固醇（TC）、低密度脂蛋白胆固醇（LDL-C）、甘油三酯（TG）浓度以及TC/高密度脂蛋白胆固醇（HDL-C）比值，还提高了HDL-C水平。此外，进行了固相萃取（SPE）以获得具有降胆固醇活性的生物活性组分。SPE的高极性组分使血清中的HDL-C升高了42%，并使TC水平降低了53.3%，LDL-C降低了47%，TG降低了50.7%，同时TC/HDL-C比值降低了69.1%。活性组分的气相色谱-质谱（GC-MS）结果显示有两种主要化合物，异山梨醇和赤藓糖醇，它们具有冠状动脉血管舒张化合物的作用。
