IGM-CNR, Via Abbiategrasso 207, Pavia 27100, Italy.
Cells. 2012 Aug 13;1(3):520-34. doi: 10.3390/cells1030520.
Autophagy is a housekeeping survival mechanism with a protective function against stress conditions. However, when stress severity or duration increases, it may promote cell death. Paradoxically, autophagy favors cancer development, since cancer cells could enhance their proliferation potential (thus becoming able to resist anticancer therapy) thanks to the energetic supply provided by organelle degradation typically driven by autophagy following a stepwise pathway. The main actors of the autophagic machinery as well as the features shared with apoptosis will be described. Special attention will be paid to the effects of autophagy manipulation.
自噬是一种维持细胞生存的自我保护机制，具有应对应激条件的功能。然而，当应激的严重程度或持续时间增加时，它可能会促进细胞死亡。自相矛盾的是，自噬有利于癌症的发展，因为癌细胞可以通过逐步途径驱动的细胞器降解来增强其增殖潜力（从而能够抵抗抗癌治疗），从而获得能量供应。将描述自噬机制的主要参与者以及与细胞凋亡的共同特征。将特别关注自噬操作的影响。
