Parikh Neil G, Junaid Imran, Sheinkopf Lee, Randhawa Inderpal, Santiago Silverio M, Klaustermeyer William B
Division of Allergy and Immunology, Veterans Affairs Greater Los Angeles Healthcare Systems/The David Geffen School of Medicine at University of California-Los Angeles, Los Angeles, California, USA.
Am J Rhinol Allergy. 2014 Jan-Feb;28(1):e52-5. doi: 10.2500/ajra.2014.28.3977.
Obstructive sleep apnea syndrome (OSAS) and allergic rhinitis (AR) are common coexisting disorders. Upper airway, specifically nasal resistance, is thought to increase during exacerbations of AR and nonallergic rhinitis (NAR), as well as in OSAS. The study objective was to determine if a correlation exists between clinical control of rhinitis and OSAS.
This prospective study followed 43 patients with concurrent OSAS and AR or NAR. OSAS was diagnosed by polysomnography, and AR or NAR was diagnosed by history, skin testing, serum-specific IgE, and total IgE levels. Measurements of control of OSAS included the Epworth Sleepiness Scale (ESS) survey and compliance with continuous positive airway pressure (CPAP) device. Measurements of rhinitis control included Assessment of Nasal Symptom Severity and Assessment of Nonnasal Symptom Severity (NSS refers to both) and Global Assessment of Nasal and Nonnasal Symptom Severity surveys (GSS). Higher NSS scores correlate with more rhinitis symptoms, whereas higher GSS scores correlate with less symptoms.
All patients completed the study. There was a positive correlation between ESS and NSS scores (p < 0.001), inverse correlation between ESS and GSS scores (p < 0.001), inverse correlation between CPAP compliance and NSS scores (p < 0.001), and positive correlation between CPAP compliance and GSS scores (p < 0.001). There was no statistically significant difference between the AR, NAR, and AR/NAR groups.
Our study showed a statistically significant positive correlation between clinical control of rhinitis symptoms and clinical control of OSAS. This study emphasizes the importance of achieving concurrent optimal control of both OSAS and AR/NAR.
阻塞性睡眠呼吸暂停综合征（OSAS）和变应性鼻炎（AR）是常见的并存疾病。上气道，特别是鼻阻力，被认为在AR和非变应性鼻炎（NAR）加重期间以及OSAS中会增加。本研究的目的是确定鼻炎的临床控制与OSAS之间是否存在相关性。
这项前瞻性研究对43例同时患有OSAS和AR或NAR的患者进行了随访。通过多导睡眠图诊断OSAS，通过病史、皮肤试验、血清特异性IgE和总IgE水平诊断AR或NAR。OSAS控制的测量包括爱泼沃斯嗜睡量表（ESS）调查和持续气道正压通气（CPAP）设备的依从性。鼻炎控制的测量包括鼻症状严重程度评估和非鼻症状严重程度评估（NSS指两者）以及鼻和非鼻症状严重程度总体评估调查（GSS）。较高的NSS评分与更多的鼻炎症状相关，而较高的GSS评分与较少的症状相关。
所有患者均完成了研究。ESS与NSS评分之间存在正相关（p < 0.001），ESS与GSS评分之间存在负相关（p < 0.001），CPAP依从性与NSS评分之间存在负相关（p < 0.001），CPAP依从性与GSS评分之间存在正相关（p < 0.001）。AR、NAR和AR/NAR组之间没有统计学上的显著差异。
我们的研究表明，鼻炎症状的临床控制与OSAS的临床控制之间存在统计学上的显著正相关。本研究强调了同时实现OSAS和AR/NAR最佳控制的重要性。
