Cejas Daniela, Vignoli Rafael, Quinteros Mirta, Marino Ricardo, Callejo Raquel, Betancor Laura, Gutkind Gabriel O, Radice Marcela A
Cátedra de Microbiología, Facultad de Farmacia y Bioquímica, Universidad de Buenos Aires, Ciudad Autónoma de Buenos Aires, Argentina.
Departamento de Bacteriología y Virología, Instituto de Higiene, Facultad de Medicina, Universidad de la República, Montevideo, Uruguay.
Rev Argent Microbiol. 2014 Jan-Mar;46(1):30-3. doi: 10.1016/S0325-7541(14)70044-6.
Salmonella enterica serovar Heidelberg ranks among the most prevalent causes of human salmonellosis in the United States and Canada, although it has been infrequently reported in South American and European countries. Most Salmonella infections are self-limiting; however, some invasive infections require antimicrobial therapy. In this work we characterized an oxyimino-cephalosporin resistant S. Heidelberg isolate recovered from an inpatient in a Buenos Aires hospital. CMY-2 was responsible for the β-lactam resistance profile. S. Heidelberg contained a 97kb plasmid belonging to the Inc N group harboring blaCMY-2. ISEcp1 was located upstream blaCMY-2 driving its expression and mobilization. The isolate belonged to sequence type 15 and virotyping revealed the presence of sopE gene. In this study we identified the first CMY-2 producing isolate of S. Heidelberg in Argentina and even in South America.
肠炎沙门氏菌海德堡血清型是美国和加拿大人类沙门氏菌病最常见的病因之一，尽管在南美和欧洲国家鲜有报道。大多数沙门氏菌感染是自限性的；然而，一些侵袭性感染需要抗菌治疗。在这项工作中，我们对从布宜诺斯艾利斯一家医院的一名住院患者身上分离出的一株对氧亚氨基头孢菌素耐药的海德堡沙门氏菌进行了特征分析。CMY-2导致了β-内酰胺耐药谱。海德堡沙门氏菌含有一个属于Inc N组的97kb质粒，携带blaCMY-2。ISEcp1位于blaCMY-2上游，驱动其表达和转移。该分离株属于序列型15，病毒分型显示存在sopE基因。在本研究中，我们在阿根廷乃至南美鉴定出了第一株产CMY-2的海德堡沙门氏菌分离株。
