中药舒血宁注射液对大鼠随意皮瓣存活的影响。
Effects of traditional Chinese medicine Shuxuetong injection on random skin flap survival in rats.
作者信息
Cai Leyi, Huang Wenfang, Lin Dingsheng
机构信息
Department of Hand and Plastic Surgery, The Second Affiliated Hospital of Wenzhou Medical University, No. 109, XueYuan Road (West), Lucheng, Wenzhou, Zhejiang 325000, China.
Department of Anesthesia, The Children's Hospital Zhejiang University School of Medicine, No. 57 Zhugan Lane, Hangzhou, Zhejiang 310006, China.
出版信息
ScientificWorldJournal. 2014 Feb 26;2014:816545. doi: 10.1155/2014/816545. eCollection 2014.
BACKGROUND
A Shuxuetong injection is traditionally used in Chinese medicine to treat "blood stasis and stagnation" (yu xue yu zhi). We investigated the effect of such injection on the survival of random skin flaps.
METHODS
McFarlane flaps were established in 60 rats divided into two groups. Postoperative celiac injections were given to both groups for 7 days. Shuxuetong was injected into the test group, and saline was injected into controls. On day 7, tissues were stained with H&E (hematoxylin-eosin) stain, immunohistochemically evaluated, and the expression levels of xanthine oxidase were determined.
RESULT
The mean area of flap survival in the test group was significantly higher than in controls. Expression of vascular endothelial growth factor and superoxide dismutase, and microvessel development, were markedly increased in the test group, and the malondialdehyde level was reduced.
CONCLUSION
Shuxuetong promotes random skin flap survival.
背景
舒血宁注射液在传统中医中用于治疗“瘀血阻滞”。我们研究了这种注射液对随意皮瓣存活的影响。
方法
将60只大鼠制成麦克法兰皮瓣并分为两组。两组术后均腹腔注射7天。试验组注射舒血宁，对照组注射生理盐水。第7天，对组织进行苏木精-伊红（H&E）染色、免疫组化评估，并测定黄嘌呤氧化酶的表达水平。
结果
试验组皮瓣存活的平均面积显著高于对照组。试验组血管内皮生长因子和超氧化物歧化酶的表达以及微血管生成明显增加，丙二醛水平降低。
结论
舒血宁可促进随意皮瓣存活。
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