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基于聚丙烯酰胺的生物相容性纳米平台增强了叶绿素类似物的肿瘤摄取、PET/荧光成像及抗癌活性。

Polyacrylamide-based biocompatible Nanoplatform enhances the tumor uptake, PET/fluorescence imaging and anticancer activity of a chlorophyll analog.

作者信息

Gupta Anurag, Wang Shouyan, Marko Aimee, Joshi Penny, Ethirajan Manivannan, Chen Yihui, Yao Rutao, Sajjad Munawwar, Kopelman Raoul, Pandey Ravindra K

机构信息

1. PDT Center, Cell Stress Biology, Roswell Park Cancer Institute, Buffalo, NY 14263, USA;

2. Department of Chemistry, University of Michigan, Ann Arbor, Michigan 48109, USA;

出版信息

Theranostics. 2014 Mar 16;4(6):614-28. doi: 10.7150/thno.8478. eCollection 2014.

DOI:10.7150/thno.8478
PMID:24723983
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3982132/
Abstract

In this report we demonstrate the outstanding advantages of multifunctional nanoplatforms for cancer-imaging and therapy. The non-toxic polyacrylamide (PAA) nanoparticles (size:18-25 nm) formulation drastically changed the pharmacokinetic profile of the ¹²⁴I- labeled chlorophyll-a derivative (formulated in 10% ethanol in PBS) with a remarkable enhancement in tumor uptake, and significantly reduced uptake in spleen and liver. Among the various nanoformulations investigated, the ¹²⁴I- labeled photosensitizer (dose: 0.6142 MBq), and the cyanine dye-nanoparticles (CD-NP) conjugate (dose 0.3 μmol/kg) in combination showed great potential for tumor imaging (PET/NIR fluorescence) in BALB/c mice bearing Colon26 tumors. Compared to free non-labeled photosensitizer, the corresponding PAA nanoformulation under similar treatment parameters showed a remarkable enhancement in long-term tumor cure by PDT (photodynamic therapy) and provides an opportunity to develop a single nanoplatform for tumor-imaging (PET/fluorescence) and phototherapy, a practical "See and Treat" approach.

摘要

在本报告中，我们展示了多功能纳米平台在癌症成像和治疗方面的突出优势。无毒的聚丙烯酰胺（PAA）纳米颗粒（尺寸：18 - 25纳米）制剂极大地改变了¹²⁴I标记的叶绿素-a衍生物（在PBS中10%乙醇中配制）的药代动力学特征，显著提高了肿瘤摄取，并显著降低了在脾脏和肝脏中的摄取。在所研究的各种纳米制剂中，¹²⁴I标记的光敏剂（剂量：0.6142 MBq）与花菁染料纳米颗粒（CD-NP）缀合物（剂量0.3 μmol/kg）联合使用，在携带Colon26肿瘤的BALB/c小鼠中显示出在肿瘤成像（PET/近红外荧光）方面的巨大潜力。与游离的未标记光敏剂相比，在相似治疗参数下相应的PAA纳米制剂通过光动力疗法（PDT）在长期肿瘤治愈方面显示出显著增强，并为开发用于肿瘤成像（PET/荧光）和光疗的单一纳米平台提供了机会，这是一种实用的“可视即治疗”方法。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7a5c/3982132/c12f556ef20b/thnov04p0614g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7a5c/3982132/e42d7a1bfbfa/thnov04p0614g001.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7a5c/3982132/2a2d6e0799f2/thnov04p0614g008.jpg
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