Nikpour Parvaneh, Emadi-Baygi Modjtaba, Emadi-Andani Elaheh, Rahmati Shima
Pediatric Inherited Diseases Research Center, Isfahan University of Medical Sciences, Isfahan, Iran,
Med Oncol. 2014 May;31(5):955. doi: 10.1007/s12032-014-0955-y. Epub 2014 Apr 12.
As the second most frequent cause of cancer death, gastric cancer is a common disease worldwide. Most of the patients are being diagnosed in the stage that conventional treatments are not effective, and invasion and metastases lead to death. So, identification of novel molecular markers to improve early diagnosis, prognosis and treatment of the gastric cancer is a necessity. EYA1 is a member of EYA family which their deregulation has been demonstrated in several types of cancer. The aim of this study was to assess EYA1 gene expression in tissues of the gastric cancer patients and to investigate its correlation with clinicopathological parameters. A total of 60 tumor and non-tumor gastric specimens were evaluated for EYA1 gene expression using quantitative real-time PCR. The EYA1 expression decreased significantly in gastric tumor tissues compared with adjacent normal tissues. We further showed that there was a negative correlation between the EYA1 gene expression levels, tumor size, lymphatic invasion and distant metastasis. In conclusion, EYA1 might be used as a potential biomarker for monitoring gastric carcinoma progression rate. Further studies to determine the mechanism of action of EYA1 is needed to unravel the role of this gene in gastric cancer pathogenesis.
作为癌症死亡的第二大常见原因，胃癌是一种全球范围内的常见疾病。大多数患者在传统治疗无效的阶段被诊断出来，侵袭和转移导致死亡。因此，识别新的分子标志物以改善胃癌的早期诊断、预后和治疗是必要的。EYA1是EYA家族的成员，其失调已在几种癌症中得到证实。本研究的目的是评估EYA1基因在胃癌患者组织中的表达，并研究其与临床病理参数的相关性。使用定量实时PCR对总共60个肿瘤和非肿瘤胃标本进行EYA1基因表达评估。与相邻正常组织相比，胃癌组织中EYA1表达显著降低。我们进一步表明，EYA1基因表达水平与肿瘤大小、淋巴侵袭和远处转移之间存在负相关。总之，EYA1可能用作监测胃癌进展率的潜在生物标志物。需要进一步研究以确定EYA1的作用机制，以阐明该基因在胃癌发病机制中的作用。
