Orr Michael S
US Food and Drug Administration, Toxicology and Environmental Science Branch, Office of Science, Center for Tobacco Products, , Rockville, Maryland, USA.
Tob Control. 2014 May;23 Suppl 2(Suppl 2):ii18-22. doi: 10.1136/tobaccocontrol-2013-051474.
To review the available evidence evaluating the toxicological profiles of electronic cigarettes (e-cigarettes) in order to understand the potential impact of e-cigarettes on individual users and the public health.
Systematic literature searches were conducted between October 2012 and October 2013 using five electronic databases. Search terms such as 'e-cigarettes' and 'electronic delivery devices' were used to identify the toxicology information for e-cigarettes.
As of October 2013, the scientific literature contains very limited information regarding the toxicity of e-cigarettes commercially available in the USA. While some preliminary toxicology data suggests that e-cigarette users are exposed to lower levels of toxicants relative to cigarette smokers, the data available is extremely limited at this time. At present, there is insufficient toxicological data available to perform thorough risk assessment analyses for e-cigarettes; few toxicology studies evaluating e-cigarettes have been conducted to date, and standard toxicological testing paradigms have not been developed for comparing disparate types of tobacco products such as e-cigarettes and traditional cigarettes.
Overall, the limited toxicology data on e-cigarettes in the public domain is insufficient to allow a thorough toxicological evaluation of this new type of tobacco product. In the future, the acquisition of scientific datasets that are derived from scientifically robust standard testing paradigms, include comprehensive chemical characterisation of the aerosol, provide information on users' toxicant exposure levels, and from studies replicated by independent researchers will improve the scientific community's ability to perform robust toxicological evaluations of e-cigarettes.
回顾现有证据，评估电子烟的毒理学特征，以了解电子烟对个人使用者和公众健康的潜在影响。
2012年10月至2013年10月期间，使用五个电子数据库进行了系统的文献检索。使用“电子烟”和“电子输送装置”等检索词来识别电子烟的毒理学信息。
截至2013年10月，科学文献中关于美国市场上可买到的电子烟毒性的信息非常有限。虽然一些初步的毒理学数据表明，与吸烟者相比，电子烟使用者接触的有毒物质水平较低，但目前可得的数据极其有限。目前，没有足够的毒理学数据来对电子烟进行全面的风险评估分析；迄今为止，很少有评估电子烟的毒理学研究，而且尚未开发出标准的毒理学测试范式来比较电子烟和传统香烟等不同类型的烟草产品。
总体而言，公共领域中关于电子烟的有限毒理学数据不足以对这种新型烟草产品进行全面的毒理学评估。未来，获取源自科学可靠的标准测试范式的科学数据集，包括对气溶胶进行全面的化学表征，提供使用者接触有毒物质水平的信息，以及来自独立研究人员重复研究的数据集，将提高科学界对电子烟进行可靠毒理学评估的能力。
