Department of Behavioral Neuroscience and Advanced Imaging Research Center, Oregon Health and Science University, Portland, Oregon 97239, Center for Neuroscience, University of California, Davis, California 95616, Division of Neuroscience, Oregon National Primate Research Center, Beaverton, Oregon 97006, and Department of Biomedical Engineering, Tecnologico de Monterrey, Campus Monterrey, Nuevo Leon, Mexico 64849.
J Neurosci. 2014 Apr 16;34(16):5552-63. doi: 10.1523/JNEUROSCI.4229-13.2014.
Resting state functional connectivity MRI (rs-fcMRI) may provide a powerful and noninvasive "bridge" for comparing brain function between patients and experimental animal models; however, the relationship between human and macaque rs-fcMRI remains poorly understood. Here, using a novel surface deformation process for species comparisons in the same anatomical space (Van Essen, 2004, 2005), we found high correspondence, but also unique hub topology, between human and macaque functional connectomes. The global functional connectivity match between species was moderate to strong (r = 0.41) and increased when considering the top 15% strongest connections (r = 0.54). Analysis of the match between functional connectivity and the underlying anatomical connectivity, derived from a previous retrograde tracer study done in macaques (Markov et al., 2012), showed impressive structure-function correspondence in both the macaque and human. When examining the strongest structural connections, we found a 70-80% match between structural and functional connectivity matrices in both species. Finally, we compare species on two widely used metrics for studying hub topology: degree and betweenness centrality. The data showed topological agreement across the species, with nodes of the posterior cingulate showing high degree and betweenness centrality. In contrast, nodes in medial frontal and parietal cortices were identified as having high degree and betweenness in the human as opposed to the macaque. Our results provide: (1) a thorough examination and validation for a surface-based interspecies deformation process, (2) a strong theoretical foundation for making interspecies comparisons of rs-fcMRI, and (3) a unique look at topological distinctions between the species.
静息态功能磁共振成像（rs-fcMRI）可能为比较患者和实验动物模型的大脑功能提供了一种强大的、非侵入性的“桥梁”；然而，人类和猕猴 rs-fcMRI 之间的关系仍知之甚少。在这里，我们使用一种新的表面变形过程，在相同的解剖空间中进行物种比较（Van Essen，2004，2005），发现人类和猕猴功能连接组之间具有高度的对应性，但也具有独特的枢纽拓扑结构。物种之间的全局功能连接匹配度为中度至高度（r = 0.41），当考虑最强的前 15%连接时，匹配度增加（r = 0.54）。对功能连接与以前在猕猴中进行的逆行示踪研究得出的基础解剖连接之间的匹配的分析表明，在猕猴和人类中都有令人印象深刻的结构-功能对应关系。当检查最强的结构连接时，我们发现两种物种的结构和功能连接矩阵之间有 70-80%的匹配。最后，我们使用两种广泛用于研究枢纽拓扑的度量标准来比较物种：度和介数中心性。数据显示，两种物种之间存在拓扑一致性，后扣带回的节点具有高的度和介数中心性。相比之下，在人类中，而不是在猕猴中，额内和顶叶皮质中的节点被确定为具有高的度和介数中心性。我们的结果提供了：（1）对基于表面的种间变形过程的全面检查和验证；（2）进行 rs-fcMRI 种间比较的坚实理论基础；（3）对物种之间拓扑差异的独特观察。
