Bergler W, Bier H, Ganzer U
Department of Oto-Rhino-Laryngology, University of Heidelberg, Mannheim, Federal Republic of Germany.
Arch Otorhinolaryngol. 1989;246(3):121-5. doi: 10.1007/BF00456651.
Representative tumor samples and mucosal samples were taken from three different groups of patients and were stained immunohistochemically for their expressions of epidermal growth factor receptors (EGFR). Patients in group 1 had oral squamous carcinoma, with specimens taken from the tumor as well as from the mucosa without tumor invasion. Patients in group 2 had no evidence of tumor but had heavy drinking and smoking habits. Tumor-free patients who do not drink or smoke served as the control group. The findings in the present study showed that the tumor and mucosal samples from groups 1 and 2 had increased EGFR expression while the control group showed significantly less EGFR. These results suggest that EGFR may play a role in the development of premalignant tissue changes, which are probably influenced by chronic toxic irritation.
从三组不同的患者身上采集了代表性肿瘤样本和黏膜样本，并对其表皮生长因子受体（EGFR）的表达进行免疫组织化学染色。第一组患者患有口腔鳞状癌，样本取自肿瘤部位以及未受肿瘤侵犯的黏膜。第二组患者没有肿瘤迹象，但有大量饮酒和吸烟习惯。不饮酒不吸烟的无肿瘤患者作为对照组。本研究结果表明，第一组和第二组的肿瘤和黏膜样本中EGFR表达增加，而对照组的EGFR表达明显较少。这些结果表明，EGFR可能在癌前组织变化的发展中起作用，而癌前组织变化可能受慢性毒性刺激影响。
