抗环瓜氨酸肽抗体与类风湿关节炎患者的间质性肺疾病相关。
Anti-cyclic citrullinated Peptide antibody is associated with interstitial lung disease in patients with rheumatoid arthritis.
作者信息
Yin Yufeng, Liang Di, Zhao Lidan, Li Yang, Liu Wei, Ren Yan, Li Yongzhe, Zeng Xiaofeng, Zhang Fengchun, Tang Fulin, Shan Guangliang, Zhang Xuan
机构信息
Department of Rheumatology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Department of Radiology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
出版信息
PLoS One. 2014 Apr 17;9(4):e92449. doi: 10.1371/journal.pone.0092449. eCollection 2014.
OBJECTIVE
Patients with rheumatoid arthritis (RA) are at risk to develop RA-associated interstitial lung disease (RA-ILD). This retrospective study aimed to investigate the potential association of the positivity of serum anti-cyclic citrullinated peptide antibody (anti-CCP2) and rheumatoid factor (RF) with RA-ILD in RA patients.
METHODS
A total of 285 RA patients were recruited at the inpatient service of Peking Union Medical College Hospital in China between 2004 and 2013. Individual patients were evaluated for the evidence of ILD. The concentrations of serum anti-CCP2 and RF in individual patients were measured. The potential risk factors for ILD in RA patients were assessed by univariate and multivariate models.
RESULTS
There were 71 RA patients with RA-ILD, accounting for 24.9% in this population. The positive rates of anti-CCP2 and RF in the patients with RA-ILD were significantly higher than that in the patients with RA-only (88.7% vs. 67.3%, p<0.001; 84.5% vs. 70.6%, p = 0.02, respectively). Univariate and multivariate logistic regression analysis revealed that RA patients with positive serum anti-CCP2, but not RF, were associated with an increased risk of ILD (crude odds ratio [cOR] 3.83, 95% confidence interval [CI] 1.74-8.43, p<0.001; adjusted odds ratio [aOR] 3.50, 95% CI 1.52-8.04, p<0.001).
CONCLUSION
Our findings suggest that positive serum anti-CCP2, but not RF, may be associated with RA-ILD in RA patients.
目的
类风湿关节炎（RA）患者有发生类风湿关节炎相关间质性肺病（RA-ILD）的风险。这项回顾性研究旨在调查血清抗环瓜氨酸肽抗体（抗CCP2）和类风湿因子（RF）阳性与RA患者发生RA-ILD之间的潜在关联。
方法
2004年至2013年期间，在中国北京协和医院住院部招募了总共285例RA患者。对个体患者进行ILD证据评估。测量个体患者血清抗CCP2和RF的浓度。通过单因素和多因素模型评估RA患者发生ILD的潜在危险因素。
结果
有71例RA患者患有RA-ILD，占该人群的24.9%。RA-ILD患者中抗CCP2和RF的阳性率显著高于单纯RA患者（分别为88.7%对67.3%，p<0.001；84.5%对70.6%，p = 0.02）。单因素和多因素逻辑回归分析显示，血清抗CCP2阳性而非RF阳性的RA患者发生ILD的风险增加（粗比值比[cOR] 3.83，95%置信区间[CI] 1.74-8.43，p<0.001；调整后比值比[aOR] 3.50，95%CI 1.52-8.04，p<0.001）。
结论
我们的研究结果表明，血清抗CCP2阳性而非RF阳性可能与RA患者发生RA-ILD有关。
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