Anselmo Aaron C, Mitragotri Samir
Department of Chemical Engineering, Center for Bioengineering, University of California, Santa Barbara 93106, USA.
Department of Chemical Engineering, Center for Bioengineering, University of California, Santa Barbara 93106, USA.
J Control Release. 2014 Sep 28;190:531-41. doi: 10.1016/j.jconrel.2014.03.050. Epub 2014 Apr 18.
Cellular hitchhiking leverages the use of circulatory cells to enhance the biological outcome of nanoparticle drug delivery systems, which often suffer from poor circulation time and limited targeting. Cellular hitchhiking utilizes the natural abilities of circulatory cells to: (i) navigate the vasculature while avoiding immune system clearance, (ii) remain relatively inert until needed and (iii) perform specific functions, including nutrient delivery to tissues, clearance of pathogens, and immune system surveillance. A variety of synthetic nanoparticles attempt to mimic these functional attributes of circulatory cells for drug delivery purposes. By combining the advantages of circulatory cells and synthetic nanoparticles, many advanced drug delivery systems have been developed that adopt the concept of cellular hitchhiking. Here, we review the development and specific applications of cellular hitchhiking-based drug delivery systems.
细胞搭便车利用循环细胞来提高纳米颗粒药物递送系统的生物学效果，这类系统常常存在循环时间短和靶向性有限的问题。细胞搭便车利用循环细胞的天然能力来：（i）在脉管系统中游走同时避免被免疫系统清除，（ii）在需要之前保持相对惰性，以及（iii）执行特定功能，包括向组织递送营养物质、清除病原体和进行免疫系统监测。多种合成纳米颗粒试图模仿循环细胞的这些功能属性以用于药物递送目的。通过结合循环细胞和合成纳米颗粒的优势，已经开发出了许多采用细胞搭便车概念的先进药物递送系统。在此，我们综述基于细胞搭便车的药物递送系统的发展及具体应用。
