• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

人参提取物抗呼吸道合胞病毒感染的抗病毒活性。

Antiviral activity of ginseng extract against respiratory syncytial virus infection.

机构信息

Center for Inflammation, Immunity and Infection, Institute for Biomedical Sciences, Georgia State University, Atlanta, GA 30303, USA.

出版信息

Int J Mol Med. 2014 Jul;34(1):183-90. doi: 10.3892/ijmm.2014.1750. Epub 2014 Apr 22.

DOI:10.3892/ijmm.2014.1750
PMID:24756136
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4072342/
Abstract

Panax ginseng has been known to have a number of immuno-modulatory effects. In this study, we investigated whether Panax Korean red ginseng extract (KRGE) has in vitro and in vivo antiviral effects on respiratory syncytial virus (RSV) infection. KRGE improved the survival of human lung epithelial cells against RSV infection and inhibited RSV replication. In addition, KRGE treatment suppressed the expression of RSV-induced inflammatory cytokine genes (IL-6 and IL-8) and the formation of reactive oxygen species in epithelial cell cultures. Oral administration of mice with KRGE resulted in lowering lung viral loads after RSV infection. Additionally, the in vivo effects of KRGE showed an enhanced level of interferon-γ (IFN-γ) producing dendritic cells subsequent to RSV infection. Taken together, these results suggested that KRGE has antiviral activity against RSV infection.

摘要

人参被认为具有多种免疫调节作用。在这项研究中，我们研究了高丽红参提取物（KRGE）是否对呼吸道合胞病毒（RSV）感染具有体外和体内的抗病毒作用。KRGE 提高了人肺上皮细胞对 RSV 感染的存活率并抑制了 RSV 的复制。此外，KRGE 处理抑制了 RSV 诱导的上皮细胞培养物中炎症细胞因子基因（IL-6 和 IL-8）的表达和活性氧的形成。用 KRGE 对小鼠进行口服给药可降低 RSV 感染后的肺部病毒载量。此外，KRGE 的体内作用显示出 RSV 感染后干扰素-γ（IFN-γ）产生树突状细胞的水平增强。总之，这些结果表明 KRGE 具有针对 RSV 感染的抗病毒活性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6150/4072342/336db924c018/IJMM-34-01-0183-g07.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6150/4072342/f7d2f302a19e/IJMM-34-01-0183-g00.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6150/4072342/395f95643c90/IJMM-34-01-0183-g01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6150/4072342/40f8928f417c/IJMM-34-01-0183-g02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6150/4072342/ba3a781d082c/IJMM-34-01-0183-g03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6150/4072342/0a72265b2f9f/IJMM-34-01-0183-g04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6150/4072342/ea4cd7a22fad/IJMM-34-01-0183-g05.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6150/4072342/98fe440ea73b/IJMM-34-01-0183-g06.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6150/4072342/336db924c018/IJMM-34-01-0183-g07.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6150/4072342/f7d2f302a19e/IJMM-34-01-0183-g00.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6150/4072342/395f95643c90/IJMM-34-01-0183-g01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6150/4072342/40f8928f417c/IJMM-34-01-0183-g02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6150/4072342/ba3a781d082c/IJMM-34-01-0183-g03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6150/4072342/0a72265b2f9f/IJMM-34-01-0183-g04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6150/4072342/ea4cd7a22fad/IJMM-34-01-0183-g05.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6150/4072342/98fe440ea73b/IJMM-34-01-0183-g06.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6150/4072342/336db924c018/IJMM-34-01-0183-g07.jpg

相似文献

1
Antiviral activity of ginseng extract against respiratory syncytial virus infection.人参提取物抗呼吸道合胞病毒感染的抗病毒活性。
Int J Mol Med. 2014 Jul;34(1):183-90. doi: 10.3892/ijmm.2014.1750. Epub 2014 Apr 22.
2
Ginseng protects against respiratory syncytial virus by modulating multiple immune cells and inhibiting viral replication.人参通过调节多种免疫细胞和抑制病毒复制来预防呼吸道合胞病毒。
Nutrients. 2015 Feb 4;7(2):1021-36. doi: 10.3390/nu7021021.
3
Resveratrol Inhibits respiratory syncytial virus-induced IL-6 production, decreases viral replication, and downregulates TRIF expression in airway epithelial cells.白藜芦醇抑制呼吸道合胞病毒诱导的白细胞介素 6 产生，减少病毒复制，并下调气道上皮细胞中的 TRIF 表达。
Inflammation. 2012 Aug;35(4):1392-401. doi: 10.1007/s10753-012-9452-7.
4
Direct Inhibition of Cellular Fatty Acid Synthase Impairs Replication of Respiratory Syncytial Virus and Other Respiratory Viruses.直接抑制细胞脂肪酸合酶会损害呼吸道合胞病毒及其他呼吸道病毒的复制。
PLoS One. 2015 Dec 11;10(12):e0144648. doi: 10.1371/journal.pone.0144648. eCollection 2015.
5
Antiviral activity of ethanol extract of Lophatherum gracile against respiratory syncytial virus infection.贯叶连翘乙醇提取物抗呼吸道合胞病毒感染的抗病毒活性。
J Ethnopharmacol. 2019 Oct 5;242:111575. doi: 10.1016/j.jep.2018.10.036. Epub 2018 Nov 1.
6
Immunobiotic Lactobacillus rhamnosus improves resistance of infant mice against respiratory syncytial virus infection.免疫生物罗伊氏乳杆菌增强婴儿小鼠抵抗呼吸道合胞病毒感染的能力。
Int Immunopharmacol. 2013 Oct;17(2):373-82. doi: 10.1016/j.intimp.2013.06.024. Epub 2013 Jul 7.
7
Tangeretin from Citrus reticulate Inhibits Respiratory Syncytial Virus Replication and Associated Inflammation in Vivo.橘红黄酮苷（Tangeretin）抑制呼吸道合胞病毒在体内的复制和相关炎症反应。
J Agric Food Chem. 2015 Nov 4;63(43):9520-7. doi: 10.1021/acs.jafc.5b03482. Epub 2015 Oct 26.
8
Anti-viral activity of jatrophone against RSV-induced respiratory infection via increase in interferon-γ generating dendritic cells.飞机草抗呼吸道合胞病毒诱导的呼吸道感染的抗病毒活性通过增加产生干扰素-γ的树突状细胞。
Environ Toxicol. 2020 Aug;35(8):888-894. doi: 10.1002/tox.22925. Epub 2020 Apr 8.
9
Antiviral effects of modified dingchuan decoction against respiratory syncytial virus infection in vitro and in an immunosuppressive mouse model.定喘汤加减方抗呼吸道合胞病毒感染的体外及免疫抑制小鼠模型作用研究。
J Ethnopharmacol. 2013 May 2;147(1):238-44. doi: 10.1016/j.jep.2013.03.012. Epub 2013 Mar 15.
10
Lack of effect of bovine lactoferrin in respiratory syncytial virus replication and clinical disease severity in the mouse model.牛乳铁蛋白对呼吸道合胞病毒复制和小鼠模型临床疾病严重程度的影响。
Antiviral Res. 2013 Aug;99(2):188-95. doi: 10.1016/j.antiviral.2013.05.013. Epub 2013 Jun 2.

引用本文的文献

1
Comprehensive PRISMA Based Systematic Review: Exploring the Phytochemistry, Pharmacological Profile and Clinical aspects of .基于PRISMA的全面系统评价：探索……的植物化学、药理特性及临床方面
Curr Top Med Chem. 2025;25(2):172-195. doi: 10.2174/0115680266344493241014082257.
2
Ginseng and ginsenosides on cardiovascular and pulmonary diseases; Pharmacological potentials for the coronavirus (COVID-19).人参及人参皂苷对心血管和肺部疾病的作用；对冠状病毒（COVID-19）的药理潜力。
J Ginseng Res. 2024 Mar;48(2):113-121. doi: 10.1016/j.jgr.2023.10.002. Epub 2023 Nov 2.
3
Anti-fatigue effect from : a suggestive and promising treatment for long COVID.

本文引用的文献

1
Respiratory syncytial virus infection: mechanisms of redox control and novel therapeutic opportunities.呼吸道合胞病毒感染：氧化还原控制的机制和新的治疗机会。
Antioxid Redox Signal. 2013 Jan 10;18(2):186-217. doi: 10.1089/ars.2011.4307. Epub 2012 Sep 7.
2
Viruslike particle vaccine induces protection against respiratory syncytial virus infection in mice.病毒样颗粒疫苗可诱导小鼠抵抗呼吸道合胞病毒感染。
J Infect Dis. 2011 Oct 1;204(7):987-95. doi: 10.1093/infdis/jir474.
3
Dual functions of ginsenosides in protecting human endothelial cells against influenza H9N2-induced inflammation and apoptosis.
抗疲劳作用：对长期新冠而言是一种具有启发性且前景广阔的治疗方法。
Acupunct Herb Med. 2022 Jun;2(2):69-77. doi: 10.1097/HM9.0000000000000033. Epub 2022 Jul 8.
4
Antiviral activities of ginseng and its potential and putative benefits against monkeypox virus: A mini review.人参的抗病毒活性及其对猴痘病毒的潜在和假定益处：一篇综述。
J Ginseng Res. 2023 Apr 1;47(6):687-93. doi: 10.1016/j.jgr.2023.03.002.
5
Antiviral Potential of the Genus : An updated review on their effects and underlying mechanism of action.该属的抗病毒潜力：关于其作用效果及潜在作用机制的最新综述
J Ginseng Res. 2023 Mar;47(2):183-192. doi: 10.1016/j.jgr.2022.11.003. Epub 2022 Nov 17.
6
Antiviral Effect of Ginsenosides rk1 against Influenza a Virus Infection by Targeting the Hemagglutinin 1-Mediated Virus Attachment.人参皂苷 rk1 通过靶向血凝素 1 介导的病毒附着抑制甲型流感病毒感染的抗病毒作用。
Int J Mol Sci. 2023 Mar 4;24(5):4967. doi: 10.3390/ijms24054967.
7
Expression levels of miR-22, miR-30c, miR-145, and miR-519d and their possible associations with inflammatory markers among patients with coronary artery disease.冠心病患者中miR-22、miR-30c、miR-145和miR-519d的表达水平及其与炎症标志物的可能关联。
ARYA Atheroscler. 2022 May;18(3):1-10. doi: 10.48305/arya.v18i0.2436.
8
Effects of Plant Metabolites on the Growth of COVID-19 (Coronavirus Disease-19) Including Omicron Strain.植物代谢产物对包括奥密克戎毒株在内的新型冠状病毒肺炎（COVID-19）生长的影响
Cureus. 2022 Jul 4;14(7):e26549. doi: 10.7759/cureus.26549. eCollection 2022 Jul.
9
Can help control cytokine storm in COVID-19?能否有助于控制新冠病毒疾病中的细胞因子风暴？
J Ginseng Res. 2022 May;46(3):337-347. doi: 10.1016/j.jgr.2022.02.006. Epub 2022 Feb 25.
10
Synthesis approach-dependent antiviral properties of silver nanoparticles and nanocomposites.银纳米颗粒和纳米复合材料的合成方法依赖性抗病毒特性。
J Nanostructure Chem. 2022;12(5):809-831. doi: 10.1007/s40097-021-00465-y. Epub 2022 Jan 15.
人参皂苷在保护人内皮细胞免受 H9N2 型流感诱导的炎症和凋亡中的双重作用。
J Ethnopharmacol. 2011 Oct 11;137(3):1542-6. doi: 10.1016/j.jep.2011.08.022. Epub 2011 Aug 22.
4
N-acetyl-L-cysteine (NAC) inhibit mucin synthesis and pro-inflammatory mediators in alveolar type II epithelial cells infected with influenza virus A and B and with respiratory syncytial virus (RSV).N-乙酰半胱氨酸（NAC）可抑制甲型和乙型流感病毒以及呼吸道合胞病毒（RSV）感染的肺泡 II 型上皮细胞中粘蛋白的合成和促炎介质。
Biochem Pharmacol. 2011 Sep 1;82(5):548-55. doi: 10.1016/j.bcp.2011.05.014. Epub 2011 May 25.
5
Anti-inflammatory and Anti-oxidative Effects of Korean Red Ginseng Extract in Human Keratinocytes.红参提取物对人角质形成细胞的抗炎和抗氧化作用。
Immune Netw. 2011 Feb;11(1):42-9. doi: 10.4110/in.2011.11.1.42. Epub 2011 Feb 28.
6
Effects of Panax ginseng on tumor necrosis factor-α-mediated inflammation: a mini-review.人参对肿瘤坏死因子-α介导的炎症的影响：小型综述。
Molecules. 2011 Mar 30;16(4):2802-16. doi: 10.3390/molecules16042802.
7
Vaccination inducing broad and improved cross protection against multiple subtypes of influenza A virus.接种疫苗可诱导针对多种亚型流感病毒的广泛且改善的交叉保护作用。
Proc Natl Acad Sci U S A. 2011 Jan 11;108(2):757-61. doi: 10.1073/pnas.1012199108. Epub 2010 Dec 27.
8
The use of a neonatal mouse model to study respiratory syncytial virus infections.利用新生鼠模型研究呼吸道合胞病毒感染。
Expert Rev Anti Infect Ther. 2010 Dec;8(12):1371-80. doi: 10.1586/eri.10.125.
9
The role of cytokines and chemokines in severe respiratory syncytial virus infection and subsequent asthma.细胞因子和趋化因子在严重呼吸道合胞病毒感染和随后的哮喘中的作用。
Cytokine. 2011 Jan;53(1):1-7. doi: 10.1016/j.cyto.2010.09.011. Epub 2010 Oct 28.
10
Protective immunity against H5N1 influenza virus by a single dose vaccination with virus-like particles.单次接种病毒样颗粒对 H5N1 流感病毒的保护性免疫。
Virology. 2010 Sep 15;405(1):165-75. doi: 10.1016/j.virol.2010.05.034. Epub 2010 Jun 26.