Godinjak Zulfo, Bilalovic Nurija
Gynecology clinic, Clinical center of Sarajevo University, Sarajevo, Bosnia and Herzegovina.
Institute of Pathology, Clinical center of Sarajevo University, Sarajevo, Bosnia and Herzegovina.
Mater Sociomed. 2014 Feb;26(1):51-2. doi: 10.5455/msm.2014.26.51-52. Epub 2014 Feb 20.
The purpose of the present study is to evaluate the relationship between endometrial concentrations of estrogen and progesterone receptors throughout the menstrual cycle in women with unexplained infertility.
In forty four infertile women with unexplained infertility, biopsy of the endometrium was performed during simultaneous laparoscopy and hysteroscopy. Material was prepared for immunohistochemical staining. Forty four endometrial samples obtained from women with normal menstrual cycles were divided into four categories: early proliferative, late proliferative, early secretory and late secretory. Immunohistochemical localization of estrogen receptors (ER) and progesterone receptors (PR) was scored according to intensity of staining and proportion of cells specifically stained in glandular epithelium and stroma and results were analyzed.
The early secretory phase appeared to be period of transition from the strong and ubiquitous staining for receptor characteristic of proliferative phase of endometrium to the weak, focal pattern of estrogen receptors. Progesterone receptors in early secretory phase were of strong staining and sufficient number of stained cells.
本研究旨在评估不明原因不孕症女性整个月经周期中子宫内膜雌激素和孕激素受体浓度之间的关系。
对44例不明原因不孕症的不育女性，在腹腔镜和宫腔镜检查同步进行时取子宫内膜活检。制备材料用于免疫组织化学染色。从月经周期正常的女性获得的44份子宫内膜样本分为四类：增殖早期、增殖晚期、分泌早期和分泌晚期。根据染色强度以及腺上皮和基质中特异性染色细胞的比例，对雌激素受体（ER）和孕激素受体（PR）进行免疫组织化学定位评分，并分析结果。
分泌早期似乎是从子宫内膜增殖期特征性的受体强而普遍染色向雌激素受体弱而局灶性模式转变的时期。分泌早期的孕激素受体染色强且染色细胞数量充足。
