沃森-克里克碱基对的识别：几何选择和互变异构导致的限制与局限
Recognition of Watson-Crick base pairs: constraints and limits due to geometric selection and tautomerism.
作者信息
Westhof Eric, Yusupov Marat, Yusupova Gulnara
机构信息
Architecture et Réactivité de l'ARN, Université de Strasbourg, Institut de Biologie Moléculaire et Cellulaire CNRS, 15 rue René Descartes, F-67084 Strasbourg Cedex France.
Département de Biologie et de Génomique Structurales, Institut de Génétique et de Biologie Moléculaire et Cellulaire CNRS, INSERM, Université de Strasbourg, F-67400 Illkirch France.
出版信息
F1000Prime Rep. 2014 Apr 1;6:19. doi: 10.12703/P6-19. eCollection 2014.
The natural bases of nucleic acids have a strong preference for one tautomer form, guaranteeing fidelity in their hydrogen bonding potential. However, base pairs observed in recent crystal structures of polymerases and ribosomes are best explained by an alternative base tautomer, leading to the formation of base pairs with Watson-Crick-like geometries. These observations set limits to geometric selection in molecular recognition of complementary Watson-Crick pairs for fidelity in replication and translation processes.
核酸的天然碱基强烈倾向于一种互变异构体形式，从而确保其氢键结合潜力的忠实性。然而，在最近的聚合酶和核糖体晶体结构中观察到的碱基对，最好用另一种碱基互变异构体来解释，这导致形成具有类似沃森-克里克几何形状的碱基对。这些观察结果为复制和翻译过程中互补沃森-克里克碱基对分子识别中的几何选择设定了限制。
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