I类主要组织相容性复合体限制的T淋巴细胞对流感血凝素的识别。I类细胞毒性T淋巴细胞与抗体位点之间的重叠。
Class I major histocompatibility complex-restricted T lymphocyte recognition of the influenza hemagglutinin. Overlap between class I cytotoxic T lymphocytes and antibody sites.
作者信息
Sweetser M T, Braciale V L, Braciale T J
机构信息
Department of Pathology, Washington University School of Medicine, St. Louis, Missouri 63110.
出版信息
J Exp Med. 1989 Oct 1;170(4):1357-68. doi: 10.1084/jem.170.4.1357.
Abstract
The influenza hemagglutinin is a critical regulator of disease expression during influenza virus infection and serves as a major target for the host immune response to this pathogen. In this report, we have analyzed an immunodominant site on the hemagglutinin (residues 202-221) recognized by murine class I MHC-restricted T lymphocytes. This analysis has revealed evidence for the duplication of a T cell recognition site within the region 202-221. We have also identified critical amino acids necessary for class I-restricted T cell recognition within these two epitopes. In addition, we provide evidence that a site on the influenza hemagglutinin recognized by neutralizing antibody directly overlaps with an epitope recognized by class I MHC-restricted CTL.
摘要
流感血凝素是流感病毒感染期间疾病表现的关键调节因子，也是宿主针对该病原体的免疫反应的主要靶点。在本报告中，我们分析了血凝素上一个被小鼠I类MHC限制性T淋巴细胞识别的免疫显性位点（第202 - 221位氨基酸残基）。该分析揭示了在202 - 221区域内存在一个T细胞识别位点重复的证据。我们还确定了这两个表位中I类限制性T细胞识别所必需的关键氨基酸。此外，我们提供的证据表明，流感血凝素上一个被中和抗体识别的位点与一个被I类MHC限制性CTL识别的表位直接重叠。
相似文献
1
Class I major histocompatibility complex-restricted T lymphocyte recognition of the influenza hemagglutinin. Overlap between class I cytotoxic T lymphocytes and antibody sites.I类主要组织相容性复合体限制的T淋巴细胞对流感血凝素的识别。I类细胞毒性T淋巴细胞与抗体位点之间的重叠。
J Exp Med. 1989 Oct 1;170(4):1357-68. doi: 10.1084/jem.170.4.1357.
2
Characterization of two distinct major histocompatibility complex class I Kk-restricted T-cell epitopes within the influenza A/PR/8/34 virus hemagglutinin.甲型流感病毒A/PR/8/34血凝素中两个不同的主要组织相容性复合体I类Kk限制性T细胞表位的特征分析
J Virol. 1991 Oct;65(10):5401-9. doi: 10.1128/JVI.65.10.5401-5409.1991.
3
Class I major histocompatibility complex-restricted cytolytic T lymphocytes recognize a limited number of sites on the influenza hemagglutinin.I类主要组织相容性复合体限制的细胞毒性T淋巴细胞识别流感血凝素上有限数量的位点。
Proc Natl Acad Sci U S A. 1989 Jan;86(1):277-81. doi: 10.1073/pnas.86.1.277.
4
5
Presentation of viral antigen to class I major histocompatibility complex-restricted cytotoxic T lymphocyte. Recognition of an immunodominant influenza hemagglutinin site by cytotoxic T lymphocyte is independent of the position of the site in the hemagglutinin translation product.将病毒抗原呈递给I类主要组织相容性复合体限制的细胞毒性T淋巴细胞。细胞毒性T淋巴细胞对免疫显性流感血凝素位点的识别与该位点在血凝素翻译产物中的位置无关。
J Exp Med. 1991 Sep 1;174(3):733-6. doi: 10.1084/jem.174.3.733.
6
Influenza A virus-specific H-2d restricted cross-reactive cytotoxic T lymphocyte epitope(s) detected in the hemagglutinin HA2 subunit of A/Udorn/72.在A/Udorn/72的血凝素HA2亚基中检测到甲型流感病毒特异性的H-2d限制性交叉反应性细胞毒性T淋巴细胞表位。
Virology. 1995 Dec 20;214(2):445-52. doi: 10.1006/viro.1995.0055.
7
8
9
Diversity of the class II (I-Ak/I-Ek)-restricted T cell repertoire for influenza hemagglutinin and antigenic drift. Six nonoverlapping epitopes on the HA1 subunit are defined by synthetic peptides.II类（I-Ak/I-Ek）限制性T细胞库对流感血凝素的多样性及抗原漂移。HA1亚基上的六个非重叠表位由合成肽段确定。
J Exp Med. 1989 Aug 1;170(2):383-97. doi: 10.1084/jem.170.2.383.
10
Recognition of disparate HA and NS1 peptides by an H-2Kd-restricted, influenza specific CTL clone.一个受H-2Kd限制的流感特异性CTL克隆对不同HA和NS1肽段的识别。
Mol Immunol. 1991 Jan-Feb;28(1-2):1-7. doi: 10.1016/0161-5890(91)90080-4.
引用本文的文献
1
Evolutionary pressures rendered by animal husbandry practices for avian influenza viruses to adapt to humans.畜牧业做法给禽流感病毒带来的进化压力使其适应人类。
iScience. 2022 Mar 1;25(4):104005. doi: 10.1016/j.isci.2022.104005. eCollection 2022 Apr 15.
2
Targets for the induction of protective immunity against influenza a viruses.针对甲型流感病毒诱导保护性免疫的靶标。
Viruses. 2010 Jan;2(1):166-188. doi: 10.3390/v2010166. Epub 2010 Jan 14.
3
Broadly neutralizing DNA vaccine with specific mutation alters the antigenicity and sugar-binding activities of influenza hemagglutinin.具有特定突变的广谱中和 DNA 疫苗改变了流感血凝素的抗原性和糖结合活性。
Proc Natl Acad Sci U S A. 2011 Mar 1;108(9):3510-5. doi: 10.1073/pnas.1019744108. Epub 2011 Feb 14.
4
Conserved epitopes of influenza A virus inducing protective immunity and their prospects for universal vaccine development.诱导保护性免疫的甲型流感病毒保守表位及其用于通用疫苗开发的前景。
Virol J. 2010 Nov 30;7:351. doi: 10.1186/1743-422X-7-351.
5
Mice deficient in perforin, CD4+ T cells, or CD28-mediated signaling maintain the typical immunodominance hierarchies of CD8+ T-cell responses to influenza virus.穿孔素、CD4+ T细胞或CD28介导信号传导缺陷的小鼠，维持对流感病毒的CD8+ T细胞应答的典型免疫显性等级。
J Virol. 2002 Oct;76(20):10332-7. doi: 10.1128/jvi.76.20.10332-10337.2002.
6
Incomplete CD8(+) T lymphocyte differentiation as a mechanism for subdominant cytotoxic T lymphocyte responses to a viral antigen.不完全的CD8(+) T淋巴细胞分化作为对病毒抗原的亚显性细胞毒性T淋巴细胞反应的一种机制。
J Exp Med. 2000 May 15;191(10):1687-98. doi: 10.1084/jem.191.10.1687.
7
A lung-specific neo-antigen elicits specific CD8+ T cell tolerance with preserved CD4+ T cell reactivity. Implications for immune-mediated lung disease.一种肺特异性新抗原引发特异性CD8 + T细胞耐受，同时保留CD4 + T细胞反应性。对免疫介导的肺部疾病的影响。
J Clin Invest. 1996 Aug 15;98(4):914-22. doi: 10.1172/JCI118874.
8
Recognition of an immunoglobulin VH epitope by influenza virus-specific class I major histocompatibility complex-restricted cytolytic T lymphocytes.流感病毒特异性的I类主要组织相容性复合体限制性细胞毒性T淋巴细胞对免疫球蛋白VH表位的识别。
J Exp Med. 1994 Jan 1;179(1):195-202. doi: 10.1084/jem.179.1.195.
9
Nonconventional (TL-encoded) major histocompatibility complex molecules present processed viral antigen to cytotoxic T lymphocytes.非常规（由TL编码）主要组织相容性复合体分子将加工后的病毒抗原呈递给细胞毒性T淋巴细胞。
J Exp Med. 1991 Jul 1;174(1):133-8. doi: 10.1084/jem.174.1.133.
10
Presentation of viral antigen to class I major histocompatibility complex-restricted cytotoxic T lymphocyte. Recognition of an immunodominant influenza hemagglutinin site by cytotoxic T lymphocyte is independent of the position of the site in the hemagglutinin translation product.将病毒抗原呈递给I类主要组织相容性复合体限制的细胞毒性T淋巴细胞。细胞毒性T淋巴细胞对免疫显性流感血凝素位点的识别与该位点在血凝素翻译产物中的位置无关。
J Exp Med. 1991 Sep 1;174(3):733-6. doi: 10.1084/jem.174.3.733.
本文引用的文献
1
Structure of the haemagglutinin membrane glycoprotein of influenza virus at 3 A resolution.流感病毒血凝素膜糖蛋白在3埃分辨率下的结构
Nature. 1981 Jan 29;289(5796):366-73. doi: 10.1038/289366a0.
2
Stimulation of anti-influenza cytolytic T lymphocytes by CNBr cleavage fragments of the viral hemagglutinin.病毒血凝素的溴化氰裂解片段对抗流感细胞溶解T淋巴细胞的刺激作用。
J Immunol. 1981 Sep;127(3):1122-5.
3
Recognition by cytotoxic T lymphocytes of cells expressing fragments of the SV40 tumor antigen.细胞毒性T淋巴细胞对表达SV40肿瘤抗原片段的细胞的识别。
J Immunol. 1983 Nov;131(5):2580-6.
4
Biological properties of an influenza A virus-specific killer T cell clone. Inhibition of virus replication in vivo and induction of delayed-type hypersensitivity reactions.甲型流感病毒特异性杀伤性T细胞克隆的生物学特性。体内病毒复制的抑制及迟发型超敏反应的诱导。
J Exp Med. 1981 Aug 1;154(2):225-34. doi: 10.1084/jem.154.2.225.
5
Antigen-presenting function of the macrophage.巨噬细胞的抗原呈递功能。
Annu Rev Immunol. 1984;2:395-428. doi: 10.1146/annurev.iy.02.040184.002143.
6
Characterization of H2 influenza virus hemagglutinin with monoclonal antibodies: influence of receptor specificity.用单克隆抗体对H2流感病毒血凝素进行表征：受体特异性的影响
Virology. 1984 Oct 30;138(2):276-86. doi: 10.1016/0042-6822(84)90351-9.
7
8
In vivo effector function of influenza virus-specific cytotoxic T lymphocyte clones is highly specific.流感病毒特异性细胞毒性T淋巴细胞克隆的体内效应功能具有高度特异性。
J Exp Med. 1984 Sep 1;160(3):814-26. doi: 10.1084/jem.160.3.814.
9
Cytotoxic T lymphocyte recognition of the influenza hemagglutinin gene product expressed by DNA-mediated gene transfer.细胞毒性T淋巴细胞对通过DNA介导的基因转移所表达的流感血凝素基因产物的识别。
J Exp Med. 1984 Feb 1;159(2):341-54. doi: 10.1084/jem.159.2.341.
Zotero 插件