Molina Patricia E, Gardner Jason D, Souza-Smith Flavia M, Whitaker Annie M
Department of Physiology and Alcohol and Drug Abuse Center, Louisiana State University Health Sciences Center, New Orleans, Louisiana.
Physiology (Bethesda). 2014 May;29(3):203-15. doi: 10.1152/physiol.00055.2013.
Alcohol abuse; the most common and costly form of drug abuse, is a major contributing factor to many disease categories. The alcohol-attributable disease burden is closely related to the average volume of alcohol consumption, with dose-dependent relationships between amount and duration of alcohol consumption and the incidence of diabetes mellitus, hypertension, cardiovascular disease, stroke, and pneumonia. The frequent occurrence of alcohol use disorders in the adult population and the significant and widespread detrimental organ system effects highlight the importance of recognizing and further investigating the pathophysiological mechanisms underlying alcohol-induced tissue and organ injury.
酒精滥用是药物滥用最常见且代价高昂的形式，是许多疾病类型的主要促成因素。酒精所致疾病负担与平均酒精消费量密切相关，酒精消费量和饮酒持续时间与糖尿病、高血压、心血管疾病、中风及肺炎的发病率之间存在剂量依赖关系。酒精使用障碍在成年人群中频繁出现，且对器官系统产生重大且广泛的有害影响，这凸显了认识并进一步研究酒精所致组织和器官损伤潜在病理生理机制的重要性。
